Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis | ||
| Benha Medical Journal | ||
| Article 10, Volume 37, Issue 2, June 2020, Pages 432-438 PDF (597.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2020.97917 | ||
| Authors | ||
| Kassem Kassem1; Mohsen Abdelrazik1; Hamada Hashem2; Heba Abdelkarim3; Mona Mahmoud4 | ||
| 1Department of otorhinolaryngology, Benha faculty of medicine, Benha University, Egypt | ||
| 2Department of otorhinolaryngology, Benha faculty of medicine, Benha university, Egypt | ||
| 3Department of biochemistry, Benha faculty of medicine, Benha University, Egypt. | ||
| 4Department of otorhinolaryngology, Benha health insurance hospital, Egypt | ||
| Abstract | ||
| Objective: Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in Egyptians. Methods: we included 100 AR patients and 75 control Egyptian subjects in a case-control study. The study involved obtaining blood samples for DNA extraction, genotyping and determination of a selected single-nucleotide polymorphisms in IL-23R by performing TaqMan assay PCR. Results: A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (p 0.001). Conclusions: To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Egyptian population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified. | ||
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