Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients | ||
| Afro-Egyptian Journal of Infectious and Endemic Diseases | ||
| Article 3, Volume 6, Issue 3, September 2016, Pages 128-133 PDF (588.07 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aeji.2016.9956 | ||
| Authors | ||
| Mariam Al-Fadhli1; Mohammad Ahmed Saraya* 2 | ||
| 1Department of Medicine, Infectious Disease Hospital, Ministry of Health, Kuwait | ||
| 2Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||
| Abstract | ||
| Background and study aim: Chickenpox is highly infectious, self-limiting disease, caused by varicella-zoster virus. Thrombocytopenia frequently complicates chickenpox. This study was conducted to assess the correlation between serum interleukin 10 levels and thrombocytopenia in adult chickenpox patients. Patients and Methods: Fifty patients of chickenpox complicated by thrombocytopenia were included in this study as a patient group. Fifty patients of chickenpox with normal platelet of comparable age, race and gender were identified as a control group. All patients were diagnosed by clinical picture of chickenpox and by presence of varicella - zoster virus immunoglobulin M (VZV IgM) in the patient blood. Estimation of complete blood count, kidney function tests, liver function tests, fasting blood sugar, and levels of cytokines IL-10 and TNF-α were done in both groups on the day of admission and day of discharge. Results: At time of admission, IL-10 levels were significantly higher in patients group than in control group, while TNF-α level were not significantly different between the two groups. At time of discharge, we observed a significant decline in IL-10 levels in the patients group as compared with time of admission. A negative correlation between IL-10 levels and platelet count was observed while no correlation was found between TNF-α and platelet count. Conclusion: IL-10 level could play an important role in development of thrombocytopenia in patients with chickenpox. | ||
| Keywords | ||
| Interleukin-10; thrombocytopenia; Chickenpox | ||
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