THE PROLONGED RELEASE OF SODIUM PHENOBARBITONE FROM SOLID DISPERSION SYSTEM | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 6, Volume 6, Issue 1, June 1983, Page 81-88 PDF (265.96 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1983.100715 | ||||
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Authors | ||||
A. T. Nouh1; M. S. Mesiha2 | ||||
1Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
Abstract | ||||
Stearic acid was used for the preparation of solid dispersion systems containing sodium Phanobarbitone in ratios of 1:2,1:1, 2:1 drug: carrier respectively. The dispersion prepared by melting and sudden cooling was passed through a set of standard sieves and tested for in vitro release rate. The release was slow for large particle size fractions and for systems containing high stearic acid content. A diffusional model was assessed for the drug release from the solid dispersion by a linear correlation observed between the percent release of the drug and the square root of time. | ||||
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