EFFECT OF BINARY BLEND OF VEHICLES ON THE PHYSICAL PROPERTIES OF DIRECTLY COMPRESSED DIIODOQUIN TABLETS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 10, Volume 6, Issue 1, June 1983, Page 135-153 PDF (737.76 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1983.100951 | ||||
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| Authors | ||||
| A. E. Ahoutaleb; S. A. Tout | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Directly compressible vehicles such as Avicel, Emdex, Sugratab, Anhydrous Lactose U.S.P, STA-R 1500 starch and Fmcompress, were used either singly or in binary blends in the ratios of 1:1, 1:3 and 3:1 w/w for the preparation diiodoquin tablets. Avicel, Celutab and STA-Rx 1500 starch were found to be the most suitable single vehicles for the formulation of diiodoquin tablets. Tablets produced using STA-R and its blends with the other vehicles, disintegrated within the specified time. The best blends used for the manufacturing of directly compressed diiodoquin tablets were those containing avicel/STA-Rx 1500 starch 3:1 and 1:3. The least actual concentration of the vehicle needed for the preparation of good diiodoquin tablets was not less than 42.0% w/w. | ||||
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