SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 15, Volume 6, Issue 1, June 1983, Page 226-242 PDF (465.5 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1983.100956 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S. R. El-Shabouri; M. M. Amer; A. M. Taha; P. Y. Khashaba | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A spectrophotometric assay procedure was developed for the quantitative assay of piperazine and phenmetrazine. The method is based on the formation of enamines of these drugs by interaction with acetaldehyde. The resulting enamines interact with chloranil to form the corresponding blue aminovinylquinone which can be quantitated spectrophotometrically at lmax 320 nm for both drugs and at lmax '667 nm and 67C nm for piperazine and phenmetrazine respectively. The Beer-Lambert law adhered to over the 0.5-20 ug/ml range for both drugs at both lmax. The optimum reaction conditions and the effect of variables have been studied. The method has been applied successfully to the analysis of commercially available piperazine tablets, ampoules and effervescent granules. | ||||
|
Statistics Article View: 83 PDF Download: 122 |
||||
