Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients | ||||
Afro-Egyptian Journal of Infectious and Endemic Diseases | ||||
Article 8, Volume 10, Issue 3, September 2020, Page 287-293 PDF (350.01 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/aeji.2020.22168.1084 | ||||
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Authors | ||||
Gamal Ahmed Tawfeek1; Abd El-Raoof El-Deib1; Fadia Mostafa Attia2; Nader El-Nemr3; Asmaa Salman Faisal4; Ahmed Salman Faisal 3 | ||||
1Department of Internal Medicine, Suez Canal University, Ismaillia, 41522, Egypt | ||||
2Department of Clinical Pathology, Suez Canal University, Ismaillia, 41522, Egypt. | ||||
3Department of Endemic and Infectious Diseases, Suez Canal University, Ismaillia, 41522, Egypt. | ||||
4Department of Internal Medicine, Elkantara West Hospital-Ismailia Governorate. | ||||
Abstract | ||||
Background and study aim: Chronically Hepatitis C virus (HCV)-infected patient, develops many complications, as liver cirrhosis, diabetes, and hepatocellular carcinoma (HCC). This study aimed at evaluation of direct acting anti-viral therapy effect on insulin resistance (IR) and glycemic status in CHC patients with type 2 diabetes mellitus, 3 months after the end of treatment. Patients and Methods: This prospective work included 72 (better patients) with CHC and type 2 diabetes. All were enrolled for anti-viral therapy at the center for treatment of viral hepatitis in Ismailia Governorate during the period from September 2015 to September 2016. Data from patients’ candidate for anti-viral therapy was collected at pretreatment and after 12 weeks of therapy. The data including, FBS, IR by Homa IR index and quantitative HCV-RNA. Results: There was a significant decrease in the mean fasting blood sugar (FBS) had occurred after treatment with anti-HCV therapy (p < 0.0001). Also, a significant decrease in the mean of HOMA-IR had occurred after treatment with anti-HCV therapy (p < 0.0001). Conclusion: A significant improvement in FBS as well as IR was declared after successful HCV treatment. | ||||
Keywords | ||||
chronic hepatitis C; direct antiviral drugs; fasting blood sugar; HOMA-IR; cirrhosis | ||||
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