Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes
El-Shwiniy, W., Nassar, M., Shehata, A., El-Desoky, S. (2020). Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes. EKB Journal Management System, 63(12), 4671-4680. doi: 10.21608/ejchem.2019.16596.2011
Walaa El-Shwiniy; Mostafa Y. Nassar; A.M.A. Shehata; S. I. El-Desoky. "Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes". EKB Journal Management System, 63, 12, 2020, 4671-4680. doi: 10.21608/ejchem.2019.16596.2011
El-Shwiniy, W., Nassar, M., Shehata, A., El-Desoky, S. (2020). 'Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes', EKB Journal Management System, 63(12), pp. 4671-4680. doi: 10.21608/ejchem.2019.16596.2011
El-Shwiniy, W., Nassar, M., Shehata, A., El-Desoky, S. Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes. EKB Journal Management System, 2020; 63(12): 4671-4680. doi: 10.21608/ejchem.2019.16596.2011

Preparation, Characterization, In vitro Cell Cytotoxicity and Biological Studies of Pd(II), Ag(I), Pt(IV) and Hg(II) Piroxicam Anti-inflammatory Drug Complexes

Egyptian Journal of Chemistry
Article 1, Volume 63, Issue 12, December 2020, Page 4671-4680  XML PDF (505.2 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.16596.2011
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Authors
Walaa El-Shwiniy email orcid 1, 2; Mostafa Y. Nassar3; A.M.A. Shehata1, 4; S. I. El-Desoky3
1Department of Chemistry, College of Science, University of Bisha, Bisha, 67714 Kingdom of Saudi Arabia
2Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt
3Department of Chemistry, Faculty of Science, Benha University, Benha 13518, Egypt
4Department of Chemistry, Faculty of Science, Al Arish University, Al Arish, 45511 Egypt.
Abstract
Novel Pd(II), Ag(I), Pt(IV) and Hg(II) piroxicam (Pir) anti-inflammatory drug complexes were obtained upon the reaction of metal salts with piroxicam (Pir) in ethanol solvent at 60 °C. The proposed structure was explained with the aid of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-Vis.), magnetic calculations and thermogravimetric analyses (TG/TGA). The ratio of metal: Pir drug is found to be 1:2 in all complexes estimated by using molar ratio method. The conductance data reveal that Pd(II), Pt(II) and Hg(II) chelates are non-electrolytes except Ag(I) complex. The infrared spectrum of free piroxicam in comparison with its chelates indicated that the chelation mode occurs via the oxygen and nitrogen atoms of ν(C=O)carbonyl and ν(C=N)pyridyl, respectively. The kinetic parameters of thermogravimetric and its differential, such as activation energy, entropy of activation, enthalpy of activation, and Gibbs free energy were evaluated using Coats-Redfern and Horowitz-Metzger equations for Pir drug and its complexes. The antimicrobial tests were assessed toward some types of bacteria and fungi. The in-vitro cell cytotoxicity of the complexes in comparison with Pir against colon carcinoma (HCT-116) cell line was investigated
Keywords
Piroxicam (Pir); IR spectroscopy; Thermal analysis; Cytotoxicity
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