Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat
Refaat, R., Eldeeb, A., Bakir, M., El-Abd, E., El-Bassiouni, E. (2020). Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat. EKB Journal Management System, 4(1), 104-112. doi: 10.21608/APS.2020.2004.1030
Rowaida Refaat; Asmaa Eldeeb; Marwa Bakir; Eman I El-Abd; Emad El-Bassiouni. "Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat". EKB Journal Management System, 4, 1, 2020, 104-112. doi: 10.21608/APS.2020.2004.1030
Refaat, R., Eldeeb, A., Bakir, M., El-Abd, E., El-Bassiouni, E. (2020). 'Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat', EKB Journal Management System, 4(1), pp. 104-112. doi: 10.21608/APS.2020.2004.1030
Refaat, R., Eldeeb, A., Bakir, M., El-Abd, E., El-Bassiouni, E. Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat. EKB Journal Management System, 2020; 4(1): 104-112. doi: 10.21608/APS.2020.2004.1030

Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat

Archives of Pharmaceutical Sciences Ain Shams University
Article 9, Volume 4, Issue 1, June 2020, Page 104-112  XML PDF (638.81 K)
Document Type: Original Article
DOI: 10.21608/APS.2020.2004.1030
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Authors
Rowaida Refaat1; Asmaa Eldeeb2; Marwa Bakir2; Eman I El-Abd email orcid 3; Emad El-Bassiouni2
1Pharmacology Department, Medical Research Institute (MRI), Alexandria University, Alexandria, Egypt
2Pharmacology Department, MRI, Alexandria University, Alexandria, Egypt
3Radiation Sciences Department, Medical Research Institute, Alexandria University, Alexandria, Egypt
Abstract
Diabetic nephropathy (DN) is the most frequent cause of the end-stage renal disease (ESRD) in about 33% of diabetic patients. The present study aimed to explore the renoprotective effects of simvastatin (SV) and rosuvastatin (RSU) on the kidney of streptozotocin (STZ)-induced diabetic Sprague-Dawley (SD) rat model. As a result of induction of diabetes, serum [cystatin C, transforming growth factor-beta (TGF-β), and 8-hydroxy-2' -deoxyguanosine  (8-OHdG)] and tissue [interleukin 1 beta (IL-1β), interleukin 10 (IL-10), prostaglandin E2 (PGE2), cytochrome c, malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), GSH/GSSG ratio) markers showed significant increase than negative controls except tissue total glutathione (tGSH). Both SV and RSU significantly shifted the levels back toward near non-diabetic values. Both exerted the same renoprotective effect indicated by a significant decrease in cystatin C. However, SV significantly lowered IL-10, GSH/GSSG ratio, MDA, and 8-OHdG  than RSU. Similarly, RSU significantly lowered cytochrome c and GSSG than SV. In conclusion, SV and RSU have differential renoprotective effects via alteration of growth factor, inflammatory, oxidative stress, DNA damage, and apoptotic signaling pathways.
Keywords
Diabetic Nephropathy; Rat Model; Rosuvastatin; Simvastatin; Streptozotocin
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