EFFECT OF BINDER AND ITS CONCENTRATION ON THE PHYSICAL CHARACTERISTICS OF SULFADIAZINE GRANULES AND TABLETS PREPARED BY WET AND FLUIDIZED-BED GRANULATION METHODS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 6, Issue 2, December 1983, Page 256-270 PDF (519.81 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1983.102084 | ||||
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| Author | ||||
| A. T. I. Nouh | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Sulfadiazine was granulated by the fluidized-bed (Uni-Glatt), as well as by the conventional massing and screening (Wet granulation) methods. The effects of binder concentration and its type on the mechanical properties of granules and their corresponding tablets, as well as on disintegration time and drug content were studied. It was found that the fluidized bed method was an efficient with all tested binders to produce superior granules. However, disintegration time of the corresponding tablets was found to be increased markedly and was greatly affected by the type and the concentration of the binder. Some suggestions to overcome this problem are stated. | ||||
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