EFFECT OF PH, TEMPERATURE AND CERTAIN ADDITIVES ON THE SOLUBILIZATION OF CARBAMAZEPINE BY SELECTED NON-IONIC SURFACTANT SOLUTIONS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 6, Issue 2, December 1983, Page 321-334 PDF (485.22 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1983.102092 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. E. Aboutaleb; S. M. Ahmed | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The effect of incorporation of various organic additives on the solvent power of the different micelles for Carbamazepine was investigated. The variation in the pH value as well as the temperature of these solution on the degree of solubilization of Carbamazepine was also studied. It was found that propylene glycol increased the solvent power of the different micelles, while glycerol, and PEG 1000, 4000 and 6000 decrease their solubilizing capacity. Raising the temperature and lowering of pH value also increased the solvent power of the micelles. | ||||
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