FORMULATION AND IN-VITRO EVALUATION OF RIBOFLAVIN TABLETS PREPARED BY FLUIDIZED BED GRANULATION TECHNIQUE | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 11, Volume 6, Issue 2, December 1983, Page 387-398 PDF (336.37 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1983.102097 | ||||
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Authors | ||||
M. A. A. Kassem1; A. T. Nouh2; T. El-Bayomy3; Alaa A. A. Kassem4 | ||||
1Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt | ||||
2Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
3National Organization for Drug and Research, Giza, Egypt | ||||
4Department of Pharmaceutics, Faculty of Pharmacy, El-Azhr University, Nasr City, Cairo, Egypt | ||||
Abstract | ||||
Spray granulation technique using fluidized bed was used for preparing riboflavin granules. Five binders were used for granulation as spray liquids, Polyvinylpyrrolidone proved to be the most suitable binder followed by sodium alginate and sodium carboxy methyl cellulose. Methyl cellulose produced tablets which disintegrated within the U.S.P.XX. Limit, but of low dissolution rate; while ethyl cellulose gave tablets which did not conform to the official Limit, but the drug was released from the tablet matrix faster than from tablets prepared by methyl cellulose. | ||||
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