Physio-biochemical responses of Indian major carp Catla catla upon sub-chronic exposure to tin oxide nanoparticles
Perva, S., Swamy, K., Chandrashekar, N., Subramanian, R., Sukumaran, S., Chandra S P, S. (2020). Physio-biochemical responses of Indian major carp Catla catla upon sub-chronic exposure to tin oxide nanoparticles. EKB Journal Management System, 24(4), 509-520. doi: 10.21608/ejabf.2020.102144
Shyamala Perva; Kalpesh Swamy; Naveenkumar Chandrashekar; Raghunandakumar Subramanian; Sandya Sukumaran; Sharath Chandra S P. "Physio-biochemical responses of Indian major carp Catla catla upon sub-chronic exposure to tin oxide nanoparticles". EKB Journal Management System, 24, 4, 2020, 509-520. doi: 10.21608/ejabf.2020.102144
Perva, S., Swamy, K., Chandrashekar, N., Subramanian, R., Sukumaran, S., Chandra S P, S. (2020). 'Physio-biochemical responses of Indian major carp Catla catla upon sub-chronic exposure to tin oxide nanoparticles', EKB Journal Management System, 24(4), pp. 509-520. doi: 10.21608/ejabf.2020.102144
Perva, S., Swamy, K., Chandrashekar, N., Subramanian, R., Sukumaran, S., Chandra S P, S. Physio-biochemical responses of Indian major carp Catla catla upon sub-chronic exposure to tin oxide nanoparticles. EKB Journal Management System, 2020; 24(4): 509-520. doi: 10.21608/ejabf.2020.102144

Physio-biochemical responses of Indian major carp Catla catla upon sub-chronic exposure to tin oxide nanoparticles

Egyptian Journal of Aquatic Biology and Fisheries
Article 31, Volume 24, Issue 4, July and August 2020, Page 509-520  XML PDF (347.14 K)
Document Type: Original Article
DOI: 10.21608/ejabf.2020.102144
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Authors
Shyamala Perva; Kalpesh Swamy; Naveenkumar Chandrashekar; Raghunandakumar Subramanian; Sandya Sukumaran; Sharath Chandra S P
Abstract
Nanostructure metal oxides such as tin oxide nanoparticles due to its unique properties have been used as a photocatalyst in semiconductor industries, building optoelectronic devices and numerous other industries. However, the toxicological impact of these SnO2 nanoparticles is largely yet to be studied, particularly in the aquatic ecosystem. In this direction to evaluate the ecological impact of the SnO2 nanoparticles on aquatic organisms, selected Catla catla, freshwater fish was selected to examine the hematological and biochemical variations upon treatment with SnO2 nanoparticles. In the present study LC50 of SnO2 NPS was found to be 20 mgl-1observed for 24 h. Further 1/10th of the LC50 concentration of SnO2nps (2 mgl-1) was selected for sublethal investigation for 4-20 days with an interval of 4 days. The results showed alterations in hematological parameters with a decrease in Hemoglobin (Hb), Hematocrit test (Hct %), red blood cells (RBC) and white blood cells (WBC), while there was an increase in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) values on all days. Further evaluation demonstrated an increase in serum lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT) levels compared to control groups. Studies revealed alterations in oxidative stress markers with a significant reduction in the serum superoxide dismutase (SOD) and catalase (CAT) levels, and an increase in malondialdehyde (MDA) and decrease in gill Na+K+ATPase concentration. The studies also found increased brain glutamate concentrations indicating possible brain tissue damage. The study highlights the toxicological impact of SnO2nps and the role of certain potential biomarkers which reflect the impact of the toxicants in the aquatic environment.
 
Keywords
Indian major carp; Catlacatla oxidative stress tin oxide nanoparticles Biochemistry
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