Role of Heat Shock Protein 70 Expression in Identification of Death Due to Fatal Thermal Exposure
Elkhateeb, S., Mohammed, A., Ibraim, M., Ibrahim, T. (2020). Role of Heat Shock Protein 70 Expression in Identification of Death Due to Fatal Thermal Exposure. EKB Journal Management System, 18(2), 39-58. doi: 10.21608/zjfm.2020.32252.1055
Shereen Ahmed Elkhateeb; Azza Sobhy Mohammed; mohammed Ibraim; Taisser Refat Ibrahim. "Role of Heat Shock Protein 70 Expression in Identification of Death Due to Fatal Thermal Exposure". EKB Journal Management System, 18, 2, 2020, 39-58. doi: 10.21608/zjfm.2020.32252.1055
Elkhateeb, S., Mohammed, A., Ibraim, M., Ibrahim, T. (2020). 'Role of Heat Shock Protein 70 Expression in Identification of Death Due to Fatal Thermal Exposure', EKB Journal Management System, 18(2), pp. 39-58. doi: 10.21608/zjfm.2020.32252.1055
Elkhateeb, S., Mohammed, A., Ibraim, M., Ibrahim, T. Role of Heat Shock Protein 70 Expression in Identification of Death Due to Fatal Thermal Exposure. EKB Journal Management System, 2020; 18(2): 39-58. doi: 10.21608/zjfm.2020.32252.1055

Role of Heat Shock Protein 70 Expression in Identification of Death Due to Fatal Thermal Exposure

Zagazig Journal of Forensic Medicine
Article 4, Volume 18, Issue 2, July 2020, Page 39-58  XML PDF (1.19 MB)
Document Type: Original Article
DOI: 10.21608/zjfm.2020.32252.1055
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Authors
Shereen Ahmed Elkhateeb email 1; Azza Sobhy Mohammed1; mohammed Ibraim2; Taisser Refat Ibrahim3
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University
2Medicolegal department, Medicolegal Authority, Egypt
3Pathology Department, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Heat shock proteins (HSPs), are a group of proteins that function as intra-cellular chaperones for other proteins. They are expressed by cells in response to exposure to stress conditions. The aim of the present study was to evaluate the role of heat shock protein 70 (HSP70) expression as vitality marker in identification death due to fatal thermal exposure (fire). This study was carried out on 21 cases of fire related fatalities (group I), 21 cases of acute traumatic death without any evidence of antemortem thermal exposure (group II). All autopsy cases of group I were examined regarding the degree of burn, carbon soot aspiration and survival time. Carboxy hemoglobin (COHb) blood level was assessed. Immunohistochemical examination of lungs, kidneys, heart and liver in all cases of both groups was done. Cases of group I showed significant strong positive HSP70 immunoreactivity (grade 3) in the lung and kidney sections either with short or long survival time exposure when compared with cases of group II. Sections from heart and liver in both groups showed weak HSP70 immunoreactivity. There was no association between the degree of HSP70 expression and degree of burn, presence or absence of carbon soot and COHb concentration in blood in group I. It was concluded that the immunohistochemical investigation of HSP 70 expression in lungs and kidneys can support the proof of vitality in death due to fatal thermal exposure.
Keywords
Fatal thermal exposure; Vitality; Heat shock protein 70; Immunohistochemistry
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