Design, Synthesis, Characterization and Biological Evaluation of 6-Methoxy-2-aminobenzothioate derivatives against certain bacterial strains. | ||||
| Egyptian Journal of Chemistry | ||||
| Article 29, Volume 63, Issue 10, October 2020, Page 3891-3901 PDF (864.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.24849.2474 | ||||
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| Authors | ||||
Ahmood Kh. Juber1; Ahmed Solaiman Hamed  2; Ahmed Moussa Khalil3
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| 1Department Of Chemistry, College of Science, University of Tikrit, Iraq. | ||||
| 2Department Of Chemistry, College of Science, University of Fallujah, Iraq | ||||
| 3Radiology Department/ University of AL-Qalam , College, Iraq. | ||||
| Abstract | ||||
| The current work reports the synthesized and biological evaluation of 6-methoxy-2-amino benzothiazole (A1), which was prepared via reaction p-Ansidine with ammonium thiocyanate followed by the oxidative ring closure of the resultant thiourea with a catalytic amount of bromine, in the alkaline medium. The resulting compound(A1) underwent condensation reactions with various kinds of aldehydes to produce Hydrazones (A3a- d). 6-methoxy2-hydrazinobenzothiazole (A2) was prepared through the reaction of the compound (A1) with 99.9 % hydrazine hydrate in the presence of concentrated HCl and ethylene glycol solution. After that, the compound (A2) was reacted with ethyl acetoacetate in alcohol to yield corresponding pyrazole-6-methoxybenzothiazole (A4). Moreover, the compound (A2) was reacted with 4- substituted aromatic aldehydes in absolute ethanol to create Hydrazones (A5a-d). Synthesized compounds were investigated as anti-bacterial activity against five microorganisms:(Gram-positive: Bacillus subtilis & Staphylococcus aurea). (Gram-negative: Pseudomonas aeruginous Escherichia coli and Enterobacter) | ||||
| Keywords | ||||
| 6-methoxy-2-amino-benzothiazole; anisidine; anti-bacterial; Schiff base; heterocycles | ||||
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