Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial
Zakaria, M., Abdelwhab, A., Hassan, S. (2020). Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial. EKB Journal Management System, 66(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1537-1543. doi: 10.21608/edj.2020.26938.1092
Mai Zakaria; Amira Abdelwhab; Sandy Hassan. "Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial". EKB Journal Management System, 66, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2020, 1537-1543. doi: 10.21608/edj.2020.26938.1092
Zakaria, M., Abdelwhab, A., Hassan, S. (2020). 'Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial', EKB Journal Management System, 66(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1537-1543. doi: 10.21608/edj.2020.26938.1092
Zakaria, M., Abdelwhab, A., Hassan, S. Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial. EKB Journal Management System, 2020; 66(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1537-1543. doi: 10.21608/edj.2020.26938.1092

Effectiveness of Topical Hyaluronic Acid Versus Chlorhexidine Mouthwashes in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Clinical Trial

Egyptian Dental Journal
Article 3, Volume 66, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2020, Page 1537-1543  XML PDF (452.6 K)
Document Type: Original Article
DOI: 10.21608/edj.2020.26938.1092
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Authors
Mai Zakaria email orcid 1; Amira Abdelwhaborcid 2; Sandy Hassanorcid 3
1Oral Medicine & Periodontology Department, Faculty of Dentistry, Cairo University, Egypt.
2Oral Medicine Department, Faculty of Dentistry, October 6th University, Egypt.
3Oral Medicine & Periodontology Department, Faculty of Dentistry, Fayoum University, Egypt
Abstract
Abstract
Background: Recurrent aphthous stomatitis (RAS) is the most common disorder affecting oral mucosa. The present study was designed to assess the clinical effectiveness of utilizing topical hyaluronic acid (HA) against chlorhexidine (CHX) mouthwashes as a control in RAS treatment.
Materials and methods: Thirty-four patients with minor RAS were included in the trial. They were equally allocated into two groups with random distribution to rinse with CHX mouthwash as a control (Group I, CHX Group) and HA mouthwash in (Group II, HA group) as a study group. Evaluation of pain intensity and ulcer size were done in all study patients at baseline, 3 days and 7 days observational times. Duration of healing period was assessed in both study groups.
Results: The results demonstrated a significant lowering in pain score and ulcer size in each group. Lower mean values of these outcomes were recorded in HA group compared to CHX group at 3 days and 7 days with significant difference regarding pain score. Concerning the duration of healing a significant decrease was recorded in HA group compared to CHX group.
Conclusion: In conclusion, topical HA is a safe and effective treatment option for RAS with better pain control and healing duration.
Keywords
recurrent aphthous stomatitis; chlorhexidine; hyaluronic acid; healing; pain
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