The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma. | ||||
Egyptian Dental Journal | ||||
Article 11, Volume 66, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2020, Page 1611-1617 PDF (617.31 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/edj.2020.33181.1150 | ||||
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Authors | ||||
Maha Abdelkawy 1; Shereen Ali 2; Ahmed Nabil Fahmi3; Olfat Shaker 4 | ||||
1Lecturer of Oral Diagnosis, Oral Medicine, and Periodontology, Beni-Suef university, Egypt. | ||||
2Oral Medicine and Periodontology Faculty of Oral and Dental Medicine Cairo University | ||||
3Department of Oral Pathology, Faculty of Dentistry Beni-Suef university, Egypt | ||||
4Department of Biochemistry, Faculty of Medicine, Cairo University | ||||
Abstract | ||||
Abstract Background and Objectives: Oral squamous cell carcinoma (OSCC) is a major oral cancer representative. Squamous cell carcinoma antigen (Scc-AG) is detected in squamous cell carcinoma of oral tissues and other different tissues. Oral lichen planus (OLP) is a chronic inflammatory disease with questionable malignant transformation. Methods: Forty-five participants divided into OSCC group and two control groups: oral lichen planus as an inflammatory disease (positive control) and healthy volunteers (negative control). Clinical staging and grading of OSCC was recorded. A double-antibody sandwich enzyme-linked immunosorbent assay was used to evaluate the level of Scc-AG in serum and saliva. Results: Statistically significant difference for serum and salivary Scc-Ag, was found between the groups; OSCC, OLP on one hand and healthy controls on the other hand. No statistically significant difference was found between OSCC and OLP control groups in serum levels, while for salivary Scc-Ag a statistically significant difference was found between these two groups, with the higher values in OLP. Staging and grading in OSCC group were not found to be related to Scc-Ag level. Conclusion: Serum Scc-Ag cannot be used as a biomarker to differentiate between oral malignant and chronic inflammatory lesions. On the other hand, salivary Scc-Ag determination provides results more reliable than serum Scc-Ag and could be used in monitoring inflammatory oral disease activity as well as malignant conditions and could differentiate between them. | ||||
Keywords | ||||
Squamous Cell Carcinoma Antigen; Biomarker; Oral squamous cell carcinoma; Oral lichen Planus; Salivary biomarkers | ||||
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