The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma.
Abdelkawy, M., Ali, S., Fahmi, A., Shaker, O. (2020). The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma.. EKB Journal Management System, 66(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1611-1617. doi: 10.21608/edj.2020.33181.1150
Maha Abdelkawy; Shereen Ali; Ahmed Nabil Fahmi; Olfat Shaker. "The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma.". EKB Journal Management System, 66, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2020, 1611-1617. doi: 10.21608/edj.2020.33181.1150
Abdelkawy, M., Ali, S., Fahmi, A., Shaker, O. (2020). 'The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma.', EKB Journal Management System, 66(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1611-1617. doi: 10.21608/edj.2020.33181.1150
Abdelkawy, M., Ali, S., Fahmi, A., Shaker, O. The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma.. EKB Journal Management System, 2020; 66(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1611-1617. doi: 10.21608/edj.2020.33181.1150

The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma.

Egyptian Dental Journal
Article 11, Volume 66, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2020, Page 1611-1617  XML PDF (617.31 K)
Document Type: Original Article
DOI: 10.21608/edj.2020.33181.1150
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Authors
Maha Abdelkawy email orcid 1; Shereen Aliorcid 2; Ahmed Nabil Fahmi3; Olfat Shakerorcid 4
1Lecturer of Oral Diagnosis, Oral Medicine, and Periodontology, Beni-Suef university, Egypt.
2Oral Medicine and Periodontology Faculty of Oral and Dental Medicine Cairo University
3Department of Oral Pathology, Faculty of Dentistry Beni-Suef university, Egypt
4Department of Biochemistry, Faculty of Medicine, Cairo University
Abstract
Abstract
Background and Objectives:
Oral squamous cell carcinoma (OSCC) is a major oral cancer representative. Squamous cell carcinoma antigen (Scc-AG) is detected in squamous cell carcinoma of oral tissues and other different tissues. Oral lichen planus (OLP) is a chronic inflammatory disease with questionable malignant transformation.
Methods:
Forty-five participants divided into OSCC group and two control groups: oral lichen planus as an inflammatory disease (positive control) and healthy volunteers (negative control). Clinical staging and grading of OSCC was recorded. A double-antibody sandwich enzyme-linked immunosorbent assay was used to evaluate the level of Scc-AG in serum and saliva.
Results:
Statistically significant difference for serum and salivary Scc-Ag, was found between the groups; OSCC, OLP on one hand and healthy controls on the other hand. No statistically significant difference was found between OSCC and OLP control groups in serum levels, while for salivary Scc-Ag a statistically significant difference was found between these two groups, with the higher values in OLP. Staging and grading in OSCC group were not found to be related to Scc-Ag level.
Conclusion:
Serum Scc-Ag cannot be used as a biomarker to differentiate between oral malignant and chronic inflammatory lesions. On the other hand, salivary Scc-Ag determination provides results more reliable than serum Scc-Ag and could be used in monitoring inflammatory oral disease activity as well as malignant conditions and could differentiate between them.
Keywords
Squamous Cell Carcinoma Antigen; Biomarker; Oral squamous cell carcinoma; Oral lichen Planus; Salivary biomarkers
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