Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
Aly, N., A. E. El-Shamandy, O., M.B., S., F. Warda, F., M. Farouk, E. (2020). Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine. EKB Journal Management System, 5(3), 103-107. doi: 10.21608/javs.2020.103395
Naglaa I. Aly; Omaima A. E. El-Shamandy; Shendy M.B.; Fatma F. Warda; Ekbal M. Farouk. "Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine". EKB Journal Management System, 5, 3, 2020, 103-107. doi: 10.21608/javs.2020.103395
Aly, N., A. E. El-Shamandy, O., M.B., S., F. Warda, F., M. Farouk, E. (2020). 'Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine', EKB Journal Management System, 5(3), pp. 103-107. doi: 10.21608/javs.2020.103395
Aly, N., A. E. El-Shamandy, O., M.B., S., F. Warda, F., M. Farouk, E. Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine. EKB Journal Management System, 2020; 5(3): 103-107. doi: 10.21608/javs.2020.103395

Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

Journal of Applied Veterinary Sciences
Article 12, Volume 5, Issue 3, July 2020, Page 103-107  XML PDF (546.6 K)
Document Type: Original Article
DOI: 10.21608/javs.2020.103395
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Authors
Naglaa I. Aly email 1; Omaima A. E. El-Shamandy2; Shendy M.B.2; Fatma F. Warda2; Ekbal M. Farouk2
1Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI) Abbasia Cairo Egypt
2Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.
Abstract
In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody in vaccinated dogs using serum neutralizing antibodies test and ELISA showed that antibody titer (0.9 and 1.2352 respectively) reached a level considered protective within two weeks and increased till lasted consist ant (2.4 and 2.694)  during the experiment for about twenty-four weeks. In conclusion, the present study results indicated that the vaccine formulated according to this study procedure could provoke long-lasting protective immune response after a single dose administration without any adverse reaction.
Keywords
Carbopol; ELISA; inactivated Vaccine; Rabies
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