Hepato-renal protective effect of vitamin C against toxicity induced by ceftriaxone in rats | ||||
| Benha Veterinary Medical Journal | ||||
| Article 13, Volume 36, Issue 1, March 2019, Page 107-118 PDF (897.32 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2019.103403 | ||||
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| Authors | ||||
| Hosny Abd-El-Fadil Ibrahim1; Esraa Bahgat Shehata2; Haiam Mohammed3 | ||||
| 1Pharmacology Department , Faculty of Veterinary Medicine , Zagazig University , Egypt; | ||||
| 2Pharmacology Department , Faculty of Veterinary Medicine , Zagazig University , Egypt; Directorate of Health Affairs, Sharkia , Egypt. | ||||
| 3Physiology Department , Faculty of Veterinary Medicine , Zagazig University | ||||
| Abstract | ||||
| The current study was carried out to evaluate the effect of vitamin C on ceftriaxone induced adverse effects in rats. Twenty four adult male albino rats were randomly divided into 3 equal groups. Group(I) received 1ml saline orally once daily for 14 days. Group(II) received 1ml saline orally once daily for 7 days followed by a 7 once day-treatment with ceftriaxone intraperitoneally(180 mg/kg b.wt.). Group(III) received vitamin C orally(100 mg/kg b.wt.) once daily for 7 days , followed by a 7 once day-treatment with both oral vitamin C and intraperitoneal ceftriaxone. At the end of the experiment, half of animals were sacrificed under light ether anesthesia on 1st day post-treatment and the other half on 7th day post-treatment. Blood samples were collected for biochemical analysis. Livers and kidneys were collected for histolopathological examination. Biochemical analysis revealed a significant increase in serum levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), urea, creatinine and malondialdehyde(MDA). with a significant decrease in catalase(CAT) and superoxide dismutase (SOD) activities in ceftriaxone treated group. Group(III) showed a significant decrease in serum levels of ALT, AST, urea, creatinine and MDA, with a significant increase in CAT and SOD activities.Histopathological examination of liver and kidney of rats in group(II) showed severe hepatocellular necrosis, macrosteatosis, portal fibrosis, portal inflammatory cells infiltrations, necrotic renal tubules and glomerular changes. An improvement of histopathological pictures of liver and kidney was recorded in group(III). This study concluded that vitamin C ameliorates the biochemical and histopathological changes associated with ceftriaxone treatment in rats. | ||||
| Keywords | ||||
| Ceftriaxone; Vitamin C; Histopathology; Biochemical analysis; Rat | ||||
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