Biochemical Effect of Psidium guajava on Experimentally induced diarrhea in mice .
Abd-Elhamid, O., El-Nahas, E., Abd-Allah, A. (2019). Biochemical Effect of Psidium guajava on Experimentally induced diarrhea in mice .. EKB Journal Management System, 36(1), 184-191. doi: 10.21608/bvmj.2019.103410
Omnia Abd-Elhamid; Ehab El-Nahas; Aml Abd-Allah. "Biochemical Effect of Psidium guajava on Experimentally induced diarrhea in mice .". EKB Journal Management System, 36, 1, 2019, 184-191. doi: 10.21608/bvmj.2019.103410
Abd-Elhamid, O., El-Nahas, E., Abd-Allah, A. (2019). 'Biochemical Effect of Psidium guajava on Experimentally induced diarrhea in mice .', EKB Journal Management System, 36(1), pp. 184-191. doi: 10.21608/bvmj.2019.103410
Abd-Elhamid, O., El-Nahas, E., Abd-Allah, A. Biochemical Effect of Psidium guajava on Experimentally induced diarrhea in mice .. EKB Journal Management System, 2019; 36(1): 184-191. doi: 10.21608/bvmj.2019.103410

Biochemical Effect of Psidium guajava on Experimentally induced diarrhea in mice .

Benha Veterinary Medical Journal
Article 20, Volume 36, Issue 1, March 2019, Page 184-191  XML PDF (112.39 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2019.103410
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Authors
Omnia Abd-Elhamid1; Ehab El-Nahas2; Aml Abd-Allah3
1Department of biochemistry, Fac .of Vet. Med., Benha Univ., Egypt .
2Department of Virology, Fac .of Vet. Med., Benha Univ., Egypt.
3Department of Micro-biology and Chemistry, Fac .of Science, Benha Univ., Egypt .
Abstract
In the present study, the potential therapeutic effect of aqueous extract of  psidium guajava leaves (GLE) on serum (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Creatinine, Uric acid ,Lipase , Lactase , Na+/K+ ATPase and  NF- KB)  in mice suffering from diarrhea induced by bovine viral diarrhea virus (BVDV) infection was evaluated. Fourty –five male albino mice were divided into 3 equal groups (15 each). Group1 (normal control group), mice not infected with the virus  and served  as a control group. Group2 (diarrhea –induced group) ,mice infected with BVDV at adose of  0.25 ml once orally. Group 3 (P.guajava –treated group) ,Mice infected with BVDV at adose of 0.25 ml once  orally and  treated  orally with 0.5 ml  aqueous extract of P.guajava leaves at adose of ( 400 mg/kg b.wt  /day) for 2 weeks . blood samples were collected from all groups after 2 weeks  of treatment. The obtained  results showed that, mice infected with BVDV had a significant increase in serum level of  (glucose, creatinine, uric acid  , NF-KB , ALT and AST) Meanwhile, ( Lipase, Lactase  and Na+/K+ ATPase )activities were significantly decreased when compared to normal control group. Administration  of diarrhea-induced group  with aqueous extract of p.guajava (GLE ) significantly restored all biochemical parameters nearly to normal where serum levels of  (glucose, creatinine, uric acid  , NF-KB , ALT and AST) were significantly decreased Meanwhile, serum ( Lipase, Lactase  and Na+/K+ ATPase) activities  were significantly increased when compaered to diarrhea -induced group   .
 
Keywords
BVDV; diarrhea; GLE; Na+/K+ ATPase; NF- KB
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