Effect of cetyltrimethylammonium bromide surfactant coated Curcumin copper nanocomposite on hepatocellular carcinoma in rats
abo zaid, O., Abdelmageed, A., Badawi, A., Eid, A. (2020). Effect of cetyltrimethylammonium bromide surfactant coated Curcumin copper nanocomposite on hepatocellular carcinoma in rats. EKB Journal Management System, 38(1), 79-81. doi: 10.21608/bvmj.2020.20525.1139
Omayma A.R. abo zaid; Afaf D. Abdelmageed; Abdelfattah M. Badawi; Asmaa A.Y Eid. "Effect of cetyltrimethylammonium bromide surfactant coated Curcumin copper nanocomposite on hepatocellular carcinoma in rats". EKB Journal Management System, 38, 1, 2020, 79-81. doi: 10.21608/bvmj.2020.20525.1139
abo zaid, O., Abdelmageed, A., Badawi, A., Eid, A. (2020). 'Effect of cetyltrimethylammonium bromide surfactant coated Curcumin copper nanocomposite on hepatocellular carcinoma in rats', EKB Journal Management System, 38(1), pp. 79-81. doi: 10.21608/bvmj.2020.20525.1139
abo zaid, O., Abdelmageed, A., Badawi, A., Eid, A. Effect of cetyltrimethylammonium bromide surfactant coated Curcumin copper nanocomposite on hepatocellular carcinoma in rats. EKB Journal Management System, 2020; 38(1): 79-81. doi: 10.21608/bvmj.2020.20525.1139

Effect of cetyltrimethylammonium bromide surfactant coated Curcumin copper nanocomposite on hepatocellular carcinoma in rats

Benha Veterinary Medical Journal
Article 16, Volume 38, Issue 1, March 2020, Page 79-81  XML PDF (3.92 MB)
Document Type: Original Article
DOI: 10.21608/bvmj.2020.20525.1139
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Authors
Omayma A.R. abo zaid1; Afaf D. Abdelmageed2; Abdelfattah M. Badawi3; Asmaa A.Y Eid email 4
1BIOCHEMISTRY DEPT.FAC.VET.MED.BENHA UNIV. EGYPT.
2BIOCHEMISTRY DEPT.FAC.VET.MED. BENHA UNIV.EGYPT
3Egyption Petrolum Research Institute
4Zoology chemistry DEPT -FAC. science. Ain shams university Diploma of biochemistry & analytical chemistry -monefiya university
Abstract
This study was designed to investigate the role of (Curcumin/ Copper / cetyltrimethylammonium bromide) nano particles complex against hepatocellular carcinoma (HCC) induced in rats. Forty rats were divided into four groups. Group 1(negative control group): normal rats. Group 2 (Diethylnitrosamine) (DEN): rats administrated orally DEN with a dose of 20 mg/kg b. wt., five times a week / 6 weeks for HCC induction. Group 3 (protective ): rats were orally treated with Curcumin/ CU / CTAB (dissolved in Tween-80 (1 %) in 0.9 % normal saline) at a dose of 35 mg/kg b. wt., five times a week / 15 weeks as 2 weeks before DEN then, during administration of DEN and 15 weeks after DEN administration. Group 4 )treated group) rats treated with Curcumin/ CU/ CTAB dissolved in Tween-80 (1 %) in 0.9 % normal saline), at a dose of 35 mg/kg b. wt., five times a week / 15 weeks, following the administration of DEN for 6 weeks . Injection of DEN induced a significant increase in serum level of alpha-fetoprotein (AFP), alpha-L-fucosidase activity (AFU) and vascular endothelial growth factor (VEGF). On other hand, marked depletion in tissue antioxidants including superoxide dismutase (SOD), glutathione perioxidase (GPX) activities, and reduced glutathione (GSH) concentration. Administration of (Curcumin/ CU/ CTAB) nano composite was able to prevent cellular damage induced by reactive oxygen species (ROS) and able to make changes of tumor markers and tissue antioxidants nearly toward control.
Keywords
Hepatocellular carcinoma; Diethylnitrosamine; Curcumin; Copper; Cetyltrimethylammonium bromide
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