Hepatoprotective activity of aerial parts of Erythrina crista-galli | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Article 3, Volume 1, Issue 1, January 2017, Page 9-15 PDF (489.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aps.2017.10357 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Nahla A. Ayoub* 1; Ashraf B. Abdel-Naim2; Mohamed L. Ashour3; Naglaa S. Mostafa1 | ||||
| 1Departments of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. | ||||
| 2Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. | ||||
| 3Departments of Pharmacognosy Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| Hepatoprotective activity was measured for Erythrina crista-galli extract as well as fractions. Fractions II and III have shown a remarkable protective effect against CCl4-induced hepatocyte injury. This was evidenced by their ability to significantly ameliorate CCl4-induced elevation in ALT and AST levels. This is supported by the notion that pretreatment of hepatocytes with either Erythrina crista-galli extracts or fractions significantly alleviated CCl4- induced GSH and SOD depletion and replenished CCL4 reduction of TAC. Hepatoprotective activity mechanism is attributed at least in part, to the free radical scavenging and antioxidant activity of the phenolic compounds present in the extract proved by the phytochemical screening of the fractions. | ||||
| Keywords | ||||
| Erythrina-crista-galli; hepatoprotection | ||||
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