Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine
Barakat, W., Abdelghany, R., Nabil, M., Abd-Elaal, M. (2020). Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine. EKB Journal Management System, 29(1), 21-29. doi: 10.21608/zjps.2020.33834.1015
Waleed Barakat; Rasha Abdelghany; Mahmoud Nabil; Mohamed Abd-Elaal. "Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine". EKB Journal Management System, 29, 1, 2020, 21-29. doi: 10.21608/zjps.2020.33834.1015
Barakat, W., Abdelghany, R., Nabil, M., Abd-Elaal, M. (2020). 'Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine', EKB Journal Management System, 29(1), pp. 21-29. doi: 10.21608/zjps.2020.33834.1015
Barakat, W., Abdelghany, R., Nabil, M., Abd-Elaal, M. Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine. EKB Journal Management System, 2020; 29(1): 21-29. doi: 10.21608/zjps.2020.33834.1015

Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 29, Issue 1, June 2020, Page 21-29  XML PDF (1.28 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2020.33834.1015
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Authors
Waleed Barakat email orcid 1; Rasha Abdelghany2; Mahmoud Nabil2; Mohamed Abd-Elaal3
1Department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt and Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tabuk University, Kingdom of Saudi Arabia.
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
3Department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
Abstract
Chronic use of opioids as morphine and tramadol to control pain is associated with several side effects and tolerance to their analgesic effect and dependence. Some of the side effects of opioids can be ameliorated by naloxone, however this is associated with decreased analgesia. Nalbuphine was shown to ameliorate morphine and tramadol psychological dependence.
The current study aims to investigate the effect of co-administration of nalbuphine with morphine or tramadol on tolerance to analgesia and physical dependence and the possible involvement of norepinephrine in its effect.
Co-admistration of nalbuphine with morphine or tramadol prevented tolerance to analgesia and physical dependence that was observed with each drug alone and this was associated with prevention of the elevation in norepinephrine in the locus coereulus (LC) following naloxone administration.
These results emphasize the possible use of nalbuphine in combination with morphine or tramadol to preserve their analgesic effect and to prevent the development of dependence to their effect.
Keywords
nalbuphine; morphine; tramadol; tolerance to analgesia; dependence
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