Heterogeneous Acid Catalyzed Synthesis and Spectroscopic Characterization of Schiff Bases Derived from Chalcone Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 20, Volume 64, Issue 1, January 2021, Page 193-200 PDF (781.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.20610.2233 | ||||
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| Authors | ||||
Olayinka Oyewale Ajani   1; Emmanuel G. Jolayemi2; Fisayo Elizabeth Owolabi3; Olayinka O. Tolubolaji3; Oluwatosin Yemisi Audu 4
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| 1Department of Chemistry, College of Science and Technology. Covenant University. Km 10, Idiroko Road, PMB 1023, Ota. Ogun State, Nigeria | ||||
| 2Department of Chemistry, CST, Covenant University, Km 10, Idiroko Road, Ota, Ogun State, Nigeria | ||||
| 3Department of Chemistry, CST, Covenant University. Km 10, Idiroko Road, Ota, Ogun State, Nigeria | ||||
| 4Department of Chemistry, University of Pretoria, South Africa | ||||
| Abstract | ||||
| Schiff bases have continued to gain attention as essential building blocks and versatile pharmacophores in drug development and drug-like molecular entities. Thus, the synthesis of Schiff bases was achieved herein via facile acetic acid catalyzed synthetic transformation of chalcones. The targeted Schiff bases and related compounds 2a-m were accessed by the treatment of amines with chalcone 1 which was previously derived through Claisen-Schmidt reaction between benzaldehyde and acetone, at ambient temperature. Structural characterization was achieved via physicochemical properties and the use of IR, UV, 1H and 13C NMR which were spectroscopic techniques. The compounds have essential candidature for further study, in biological activity so as to unleash their medicinal potential. | ||||
| Keywords | ||||
| chalcone; azomethine; substituted benzaldehyde; heterogenous catalyst | ||||
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