RELEASE AND RHEOLOGICAL CHARACTERISTICS OF CHLORTETRACYCLINE HYDROCHLORIDE OPHTHALMIC OINTMENTS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 4, Issue 1, 1981, Page 82-98 PDF (539.34 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1981.104591 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| H. A. El-Sourady; M. A. Attia; S. M. El-Shanawany | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The release of chlortetracycline from absorption and emulsion ointment bases were studied. The drug release rates from the emulsion bases were found to be Higher than that from the absorption bases. The presence of sod. metabisulphite and EDTA in the ointment systems under test was found to increase the release rate of the drug. Inclusion of a buffer in the aqueous phase of the emulsion systems was found to retard the release of the drug. The rheological data reveals that there is a correlation between the breakdown of the system and the release of the drug from the system accompanying the addition of sod. Metabisulphite EDTA mixture and buffer solution to the ointment bases. | ||||
|
Statistics Article View: 78 PDF Download: 127 |
||||
