A STUDY ON THE RELATIONSHIP BETWEEN DISINTEGRATION OF DIRECTLY COMPRESSED SULPHADIMIDINE TABLETS AND THEIR PHYSIOLOGICAL AVAILABILITY IN MAN | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 3, Issue 1, 1980, Page 74-86 PDF (415.32 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1980.104713 | ||||
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| Authors | ||||
| Adel M. Sakr; Ahmed E. Aboutaleb; Hassan M. Elsabbagh; Adel M. Aly | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A study was made on the disintegration time and in vivo absorption rate of sulphadimidine tablets prepared by direct compression technique using Celutab (50% w/w) as an excipient. Tablets of greatly different disintegration times were selected for this investigation. Using urinary excretion method, it was shown that there is a relationship between disintegration time and in vivo absorption of sulphadimidine tablets, in that the tablet with faster disintegration time gives a higher absorption as indicated by the excretion rate calculated from the cummulative amount of sulphadimidine excreted. | ||||
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