EFFECT OF DIFFERENT ADDITIVES ON THE MICELLAR SOLUBILIZATION OF CHLORAMPHENICOL | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 3, Issue 1, 1980, Page 87-104 PDF (588.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1980.104720 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| A. E. Aboutaleb; A. Abdelzaher | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The effect of different inorganic and organic additives on the solubility of chloramphenicol by non-ionic surfactant solutions was investigated at two different temperatures. The following additives were used namely polyethylene glycol 600, propylene glycol, glycerol, urea and potassium chloride. Urea produced a slight effect on the solubilizing efficiency of the non-ionic surfactant solutions; on the other hand a more pronounced effect on the solubilizing efficiency of these nonionic micelles was obtained by increasing the concentration of potassium chloride in solutions. For organic additives it was found that the addition of polyethylene glycol 600 increased the solubilizing efficiency of all the non-ionic surfactant solutions than both glycerol and propylene glycol. | ||||
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