RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 11, Volume 3, Issue 1, 1980, Page 125-136 PDF (426.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1980.104723 | ||||
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| Authors | ||||
| Salwa R. El-Shabouri1; S. A. Ibrahim2 | ||||
| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A simple, rapid, selective and highly sensitive colorimetric method for the determination of isoprenaline (isoproterenol) is described. The method depends on the interaction of dimethoxydiquinone, with isoprenaline sulphate under specified conditions with the formation of a highly coloured, product which has a lmax at 5l0 nm and apparent molar absorptivity of 3.8x106. Absorbance versus concentration is linear up to 6 mcg/ml. No interference is observed in presense of common pharmaceutical adjuvants. The developed method is applicable with almost complete recovery for assaying isoprenaline in commercial, pharmaceutical dosage forms without prior separation. The proposed method is also recommended as stability indicating assay for oxidative degradation involving the catecholic function of isoprenaline. | ||||
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