FORMAZAN-INDUCED COLORIMETRIC ANALYSIS OF DIHYDRALAZINE SULFATE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 5, Volume 1, Issue 1, 1978, Page 73-86 PDF (517.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1978.104908 | ||||
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| Authors | ||||
| Nawal A. El-Rabbat; Nabil M. Omar | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A colorimetric assay procedure was developed for the quantitativ analysis of dihydralazine sulfate. The method is based-on the interaction of 2,3,5-triphenyltetrazolium chloride with dihydralazine sulfate, in presence of potassium hydroxide in absolute ethanol, to afford a highly colored and stable formazan. This could be spectrophotometrically quantified at 485 nm, with an ideal adherence to Beer's law for solutions containing 2.0-22.0 mcg dihydralazine sulfate/ml. The presented color reaction is selective; no interference could be displayed by reserpine or hydrochlorothiazide. This permitted the application of the procedure to the satisfactory analysis of commercial dihydralazine formulations without prior separation from these drugs. | ||||
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