ANALYSIS AND DISSOCIATION OF CERTAIN ACIDIC PHARMACEUTICAL COMPOUNDS IN N-BUTANOL | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 1, Issue 1, 1978, Page 115-131 PDF (492.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1978.104911 | ||||
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| Authors | ||||
| Nawal A. El-Rabbat; Mahmoud A. El-Gendy; Kamla M. Emara | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt | ||||
| Abstract | ||||
| Visual and potentiometric titrations of aspirin, benzoic acid, hydrochloric acid, nicotinic acid, perchloric acid, phenyl butazone, salicylic acid, chloropromazine hydrochloride, ephedrine hydrochloride, mepyramine maleate and procaine hydrochloride were carried out in n-butanol, using potassium butoxide as the titrant. For visual end points, thymol blue was used as indicator, while potentiometric measurements were assessed by a glass indicator electrode. The dissociation constants of' the studied compounds were determined by the use of the electromotive force method and revealed the good applicability of n-butanol as a solvent for non-aqueous titration of acidic pharmaceutical compounds. | ||||
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