Clomiphene citrate induced kidney injury in female albino rat | ||||
| Journal of Bioscience and Applied Research | ||||
| Article 1, Volume 1, Issue 2, June 2015, Page 39-43 PDF (8.27 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2015.105950 | ||||
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| Authors | ||||
| Hawazen A. Lamfon* 1; Nahid A. Lamfon2 | ||||
| 1Biology Department, Faculty of Applied Science, Umm Al- Qura University, Makkah, Saudi Arabia | ||||
| 2Consultant Family &Community Medicine, King Abullaziz medical City / National Guard Health Affair / Riyadh | ||||
| Abstract | ||||
| Clomiphene citrate (clomid), a selective oestrogen-receptor modulator, is used in the treatment of polycystic ovary syndrome. On the other hand, it showed many adverse effects. The present work investigates the effects of clomiphene citrate (CC) on kidney of female albino rats. Many biochemical and histological changes were induced in these animals when treated with CC at doses of 50 and 100 mg/kg body weight. Treating animals with doses of 50 and 100 mg/kg body weight caused elevations in serum creatinine and urea. The histological changes in the kidney of treated animals included intertubular leucocytic infiltrations, congestion of blood vessels and degeneration of renal tubules. Moreover, atrophy of glomeruli was recorded. In conclusion, biochemical and histopathological alterations indicated that clomiphene citrate causes renal damage in female albino rats | ||||
| Keywords | ||||
| Biochemistry; Clomiphene citrate; Histology; Kidney; Rats | ||||
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