Gasoline induced pulmo- oxidative damage in mice model
Ali, A., El-Ghazaly, N., Dekinesh, S., Sedky, A., Kabiel, S. (2016). Gasoline induced pulmo- oxidative damage in mice model. EKB Journal Management System, 2(1), 1-9. doi: 10.21608/jbaar.2016.106481
Awatef Ali; Nawal El-Ghazaly; Samir Dekinesh; Azza Sedky; Sanaa Kabiel. "Gasoline induced pulmo- oxidative damage in mice model". EKB Journal Management System, 2, 1, 2016, 1-9. doi: 10.21608/jbaar.2016.106481
Ali, A., El-Ghazaly, N., Dekinesh, S., Sedky, A., Kabiel, S. (2016). 'Gasoline induced pulmo- oxidative damage in mice model', EKB Journal Management System, 2(1), pp. 1-9. doi: 10.21608/jbaar.2016.106481
Ali, A., El-Ghazaly, N., Dekinesh, S., Sedky, A., Kabiel, S. Gasoline induced pulmo- oxidative damage in mice model. EKB Journal Management System, 2016; 2(1): 1-9. doi: 10.21608/jbaar.2016.106481

Gasoline induced pulmo- oxidative damage in mice model

Journal of Bioscience and Applied Research
Article 1, Volume 2, Issue 1, January 2016, Page 1-9  XML PDF (471.4 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2016.106481
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Authors
Awatef Ali* 1; Nawal El-Ghazaly1; Samir Dekinesh1; Azza Sedky1; Sanaa Kabiel2
1Zoology department –Faculty of Science –Alexandria University-Egypt
2Genetic &Biotechnology institute-City of Scientific Researches-Alexandria University- Egypt
Abstract
The present work aims to evaluatethe cytotoxic effects on lung cells exerted by gasoline. 60 male albino mice were used in the present experiment, divided equally into 3 groups: first group (control) was left access to fresh air, second group (experimental) was subjected to gasoline 80- vapor/1h./day and third group (experimental) was subjected to gasoline 90-vapor/1h./day along eight consecutive weeks. The study comprises determination of body weight, bioaccumulation of some heavy metals ,histological and ultra-changes . Histological changes increased according to duration of exposure as, infiltration of inflammatory cells, detachment and necrosis of the epithelial cells .The electron micrographs revealed dilatation of the smooth endoplasmic reticulum, loss of the secretory granules in the Clara cells and loss of cilia in the ciliated cells that exhibited bleb formation. Necrotic type II pneumocytes, exhibited vacuolation, fragmentation of the rough endoplasmic reticulum,mitochondrial degeneration , nuclear alterations, degeneration of lamellar bodies and microvillar atrophy. In conclusion, gasoline vapour inhalation induced lung tissue injury and cellular damage concomitant with impairment of the lung antioxidant defense system. These effects were more pronounced with the unleaded than with the leaded gasoline.
Keywords
Gasoline; Mice Model; Bioaccumulation; Body weight; Histology
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