Meta-Analysis of Liver Cirrhosis and The Risk of Fracture | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 30, Volume 70, Issue 8, January 2018, Page 1415-1420 PDF (537.62 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.12816/0044660 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| Background: Cirrhosis is the irreversible fibrosis of liver, it continues to be a common cause of morbidity and mortality. It is accompanied by inflammation and malnutrition and thus can have a negative effects on bone metabolism and promote fractures accordingly. Aim of the study: to evaluate the risk of fractures among patients with cirrhosis. Methods: A systematic review of the scientific literature following PRISMA/STROBE guidelines, Medline Cochrane Library and Embase abstracts were retrieved using an algorithm comprising relevant MeSH terms from 1980 to 2017. Publications on the association of cirrhosis/bone fracture were abstracted independently by the authors and included in both gender and gender-specific meta-analyses, following recalculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. Results: 8 studies met the inclusion criteria enrolling 988 patients (286 of which are diagnosed with alcoholic liver disease (ALD). Overall, ALD demonstrated a relative risk (RR) of 1.825, 95%CI: 1.370-2.28, P < 0.001 for the development of bone fractures. Bone mineral density (BMD) was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD. Sensitivity analyses showed consistent results. Conclusion: in accordance to the present meta-analysis, there is a significant correlation between bone fractures and ALD independent of BMD. | ||||
| Keywords | ||||
| Cirrhosis; bone fracture; ALD; Chronic liver disease; fibrosis; Orthopedic | ||||
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