The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.
Baghdadi, H., El-Demerdash, F., Hussein, S., Radwan, E. (2016). The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.. EKB Journal Management System, 2(3), 197-202. doi: 10.21608/jbaar.2016.106944
Hoda H. Baghdadi; Fatma M. El-Demerdash; Sodfa Hussein; Eman H. Radwan. "The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.". EKB Journal Management System, 2, 3, 2016, 197-202. doi: 10.21608/jbaar.2016.106944
Baghdadi, H., El-Demerdash, F., Hussein, S., Radwan, E. (2016). 'The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.', EKB Journal Management System, 2(3), pp. 197-202. doi: 10.21608/jbaar.2016.106944
Baghdadi, H., El-Demerdash, F., Hussein, S., Radwan, E. The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.. EKB Journal Management System, 2016; 2(3): 197-202. doi: 10.21608/jbaar.2016.106944

The protective effect of Coriandrum sativum L. oil against liver toxicity induced by Ibuprofen in rats.

Journal of Bioscience and Applied Research
Article 5, Volume 2, Issue 3, March 2016, Page 197-202  XML PDF (804.44 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2016.106944
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Authors
Hoda H. Baghdadi1; Fatma M. El-Demerdash1; Sodfa Hussein1; Eman H. Radwan2
1Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University
2Zoology Department, Faculty of Science, Damanhour University
Abstract
Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drugused in the treatment of pain, fever and in inflammation.Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluatethe protective effect of Coriandrum sativum volatile oil on hepatotoxicityof IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBU group,100mg/kg bodyweight B.W., for 14 day), group lV (IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oilin the combination with IBU was able to significantly increase the activity of both AST and ALT, in the liver and caused a significant decrease in the deleterious effect induced by IBU. The present results confirm that the antioxidant activity of volatile oil of the Coriandrum sativum L., against hepatotoxicity of IBU
Keywords
Ibuprofen; liver; Coriandrum sativum; Histopathology; Transaminases
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