EFFECT OF DELTAMETHRIN ON LIVER AND KIDNEY FUNCTION OF CLARIAS LAZERA FISH | ||||
| Kafrelsheikh Veterinary Medical Journal | ||||
| Article 12, Volume 7, Issue 1, May 2009, Page 206-232 PDF (1.77 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/kvmj.2009.107173 | ||||
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| Authors | ||||
| M. A. Aziz* 1; Hanaa Hegazi1; Menha Abd EL-Khalik2; Manal Taha3 | ||||
| 1Department of Pharmacology, and Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt | ||||
| 2Department of Biochemistry , and Feed Deficiency Diseases, Animal Health Research Institute, Dokki, Cairo, Egypt | ||||
| 3Department of Public Health and Zoonotic Diseases, Directorate of Veterinary Medicine, Kafr El- Sheikh, Egypt | ||||
| Abstract | ||||
| A total number of 160 apparently healthy male catfish (Clarias lazera) weighed 95-105 gm, and with total length of 21-25 cm were exposed to deltamethrin (DM) concentrations of 0.5 ug/L, for one week, and 0.02, and 0.01 ug/L for 4 weeks. Serum and internal organs (liver, and kidney) samples were obtained for the determination of both liver and kidney functions. Liver function tests revealed a non-significant difference in serum total bilirubin, serum total globulins (S.G.), serum albumin/globulin (A/G) ratio, serum triglycerides (TG) level, serum alanine aminotransferase activity (S.ALT), serum alkaline phosphatase activity (S.ALP), and a significant increase in serum albumin (S.A.), serum total protein (S.T.P.), serum aspartate aminotransferase (S.AST), and lactate dehydrogenase (S.LDH) activities, and a significant decrease in serum total cholesterol and serum total lipids (TL) level, by the exposure to the concentration 0.5 ug/L of DM for one week. There was also a significant increase in serum total bilirubin, S. AST, S. ALT, S.ALP, and serum LDH activities and a significant decrease in S.A. level, S.T.P. , serum A/G ratio, and a non-significant difference in S.G. content, by both concentrations 0.01, and 0.02 ug/L of DM. The concentration 0.01 ug/L of DM only significantly increased serum cholesterol, TG, and TL levels, while, the concentration 0.02 ug/L significantly decreased the serum cholesterol, TG, and TL levels. Liver tissue showed excess of melano-machrophage centers (MMCs), congestion, odema and lymphocytic infiltrations after acute exposure to the concentration 0.5 ug/L of DM for one week, while After chronic exposure there were congestion, hepatocytic degeneration and necrosis which were accompanied with excess of MMCs. Kidney function test revealed a significant increase in serum urea, serum creatinine (S.Cr.) and serum uric acid level by the concentration 0.5 ug/L for one week, and 0.02 ug/L for 4 weeks, and only and a significant increase in both urea and uric acid levels by the concentration 0.01 ug/L for 4 weeks. The renal tubules were damaged with congestion of the various glomerular as well as intertubular blood vessels in addition to several areas of hemorrhages and lymphocytic infiltration after acute exposures, while the posterior kidneys suffered damage of the glomeruli with several tubular degenerations and necrosis in addition to an excess of mononuclear cell reactions after the chronic exposure to the high concentration 0.02 ug/L of DM. | ||||
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| Keywords | ||||
| Deltamethrin: Toxicity: catfish (Clarias lazera): Liver function: Kidney function Histopathology | ||||
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