Study of Behavioral Deficits Elicited by Exposure to Lipopolysacaride /Chronic Mild Stress in Male Wistar Rats
Ebeid, M., Aboul-Fotouh, S., Abdel-tawab, A., El-Kharashi, O., Abd Al-khalek, H. (2018). Study of Behavioral Deficits Elicited by Exposure to Lipopolysacaride /Chronic Mild Stress in Male Wistar Rats. EKB Journal Management System, 72(9), 5137-5143. doi: 10.21608/ejhm.2018.10732
Mai Ahmed Ebeid; Sawsan Aboul-Fotouh; Ahmed Mohyeldin Abdel-tawab; Omnyah Aly El-Kharashi; Hadwa Ali Abd Al-khalek. "Study of Behavioral Deficits Elicited by Exposure to Lipopolysacaride /Chronic Mild Stress in Male Wistar Rats". EKB Journal Management System, 72, 9, 2018, 5137-5143. doi: 10.21608/ejhm.2018.10732
Ebeid, M., Aboul-Fotouh, S., Abdel-tawab, A., El-Kharashi, O., Abd Al-khalek, H. (2018). 'Study of Behavioral Deficits Elicited by Exposure to Lipopolysacaride /Chronic Mild Stress in Male Wistar Rats', EKB Journal Management System, 72(9), pp. 5137-5143. doi: 10.21608/ejhm.2018.10732
Ebeid, M., Aboul-Fotouh, S., Abdel-tawab, A., El-Kharashi, O., Abd Al-khalek, H. Study of Behavioral Deficits Elicited by Exposure to Lipopolysacaride /Chronic Mild Stress in Male Wistar Rats. EKB Journal Management System, 2018; 72(9): 5137-5143. doi: 10.21608/ejhm.2018.10732

Study of Behavioral Deficits Elicited by Exposure to Lipopolysacaride /Chronic Mild Stress in Male Wistar Rats

The Egyptian Journal of Hospital Medicine
Article 1, Volume 72, Issue 9, July 2018, Page 5137-5143  XML PDF (374.15 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.10732
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Authors
Mai Ahmed Ebeid email 1; Sawsan Aboul-Fotouh1, 2; Ahmed Mohyeldin Abdel-tawab1, 2; Omnyah Aly El-Kharashi1; Hadwa Ali Abd Al-khalek3
1Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Clinical Pharmacology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Department of Histology Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: depression may be considered "the disease of the modern era". With a high prevalence worldwide causing significant morbidity and mortality and constituting a heavy burden on social and economic welfare. Despite decades-long research the exact pathogenesis of depression is still not fully understood. Aims: to investigate the behvioral deficits elicited by exposure to the combined model of lipopolysaccharide (LPS) then chronic mild stress (CMS) in male Wistar rats and to investigate the putative role of inflammatory cytokine production induced lipopolysaccharide exposure together with chronic stress in the pathogenesis of depressive like behaviour. Materials and Methods: Sixty five Male Wistar rats were divided into two groups; Control group (n=29): naïve rats left undisturbed, not exposed to stress and LPS/CMS exposed group (n=27). Results: exposure to LPS/CMS model induced a depressive-like behavior manifested by a decline in body weight gain, alongside an increase in immobility time in FST and a decrease in time of active interaction in SIT. Conclusion: this work highlights the depressive like behaviour induced by exposure to the combined model of lipopolysaccharide and chronic mild stress. This work also underscores the putative role of lipopolysaccharide exposure in modulating the stress-induced neuroinflammation which is thought to be crucial, not only for the pathogenesis of depression, but also for a wide array of neurological diseases. 
Keywords
depression; chronic mild stress; lipopolysaccharide; forced swimming test; open field test; social interaction test
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