Metformin versus losartan: prevention of non-alcoholic fatty liver disease in adult albino rats, an immunohistochemical study. | ||||
| The Egyptian Journal of Anatomy | ||||
| Article 27, Volume 43, Issue 2, April 2024, Page 315-330 PDF (2.66 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejana.2020.10163.1013 | ||||
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| Authors | ||||
Reham Ismail Taha   1; Ahmed Nasr2; Rania Kamal3; Adel ElHawary2
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| 1anatomy department, faculty of medicine, Mansoura university, Mansoura, Egypt | ||||
| 2anatomy department, faculty of medicine , mansoura university | ||||
| 3Mansoura, Anatomy Dept. | ||||
| Abstract | ||||
| Non-alcoholic fatty liver disease (NAFLD) is considered a worldwide epidemic defined as the accumulation of excessive fat in the liver in the absence of excessive drinking of alcohol. Its prevalence in the Middle East ranges between 20 and 30 %. We designed this study to evaluate the preventive effect of both metformin and losartan on NAFLD in rats. We induced NAFLD by high fat diet and fructose in drinking water for 8 weeks. Twenty four rats were used in this study and randomly divided into 4 groups; control group, high fat diet group, high fat diet with metformin group and high fat diet with losartan group. Blood samples were used for detection of liver enzymes and lipid profile assessment. Paraffin and frozen liver sections were done. Metformin and losartan significantly prevented the increase in the serum levels of liver enzymes and the lipid profile induced by NAFLD in rats. Also, they partially preserved the hepatic architecture. | ||||
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