Pre-eclampsia – An excessive maternal immune response in Egyption wommen.
Soliman, M., Abd El Alim, M., Shoaip, A., Zayed, A. (2016). Pre-eclampsia – An excessive maternal immune response in Egyption wommen.. EKB Journal Management System, 2(4), 244-249. doi: 10.21608/jbaar.2016.107535
Maha G. Soliman; Mervat Abd El Alim; Ayaa A. Shoaip; Abd El-Hady A. Zayed. "Pre-eclampsia – An excessive maternal immune response in Egyption wommen.". EKB Journal Management System, 2, 4, 2016, 244-249. doi: 10.21608/jbaar.2016.107535
Soliman, M., Abd El Alim, M., Shoaip, A., Zayed, A. (2016). 'Pre-eclampsia – An excessive maternal immune response in Egyption wommen.', EKB Journal Management System, 2(4), pp. 244-249. doi: 10.21608/jbaar.2016.107535
Soliman, M., Abd El Alim, M., Shoaip, A., Zayed, A. Pre-eclampsia – An excessive maternal immune response in Egyption wommen.. EKB Journal Management System, 2016; 2(4): 244-249. doi: 10.21608/jbaar.2016.107535

Pre-eclampsia – An excessive maternal immune response in Egyption wommen.

Journal of Bioscience and Applied Research
Article 2, Volume 2, Issue 4, April 2016, Page 244-249  XML PDF (251.13 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2016.107535
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Authors
Maha G. Soliman1; Mervat Abd El Alim1; Ayaa A. Shoaip1; Abd El-Hady A. Zayed2
1Zoology Department, Faculty of Science , (girls), Al- Azhar University
2Faculty of Medicine, Mansoura University,Egypt
Abstract
Preeclampsia is a stressful condition in which many physiological and metabolic functions are altered to a considerable extent.Although pre eclampsia causes high maternal /fetal morbidity, the etiology of this multisystem disorder is still unknown. We have detected the cytokine levels inpreeclamptic women compared to normotensive pregnant and non-pregnant women.This study aimed to understand immunological network , and physiological parameters for the pathogeneses of preeclampsia.Serum levels of tumor necrosis factor alpha (TNFα ) and interleukin 10(IL-10 )were measured by enzyme-linked immunosorbent assay (ELISA) . C reactive protein (CRP) was evaluated as inflammatory marker in preeclampsia.Our findings demonstrated that pre eclamptic state is associated with high levels of pro inflammatory cytokine TNFα (p < 0.05) and C.R.P. By contrast, normotensive pregnancy evolved high levels of regulatory cytokine Il-10 .The present study supports the hypothesis of altered immune response in preeclampsia.
Keywords
C-reactive protein (CRP); pro inflammatory cytokine(TNFα ); regulatory cytokine (IL-10 )
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