Pre-eclampsia – An excessive maternal immune response in Egyption wommen. | ||||
Journal of Bioscience and Applied Research | ||||
Article 2, Volume 2, Issue 4, April 2016, Page 244-249 PDF (251.13 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jbaar.2016.107535 | ||||
View on SCiNiTO | ||||
Authors | ||||
Maha G. Soliman1; Mervat Abd El Alim1; Ayaa A. Shoaip1; Abd El-Hady A. Zayed2 | ||||
1Zoology Department, Faculty of Science , (girls), Al- Azhar University | ||||
2Faculty of Medicine, Mansoura University,Egypt | ||||
Abstract | ||||
Preeclampsia is a stressful condition in which many physiological and metabolic functions are altered to a considerable extent.Although pre eclampsia causes high maternal /fetal morbidity, the etiology of this multisystem disorder is still unknown. We have detected the cytokine levels inpreeclamptic women compared to normotensive pregnant and non-pregnant women.This study aimed to understand immunological network , and physiological parameters for the pathogeneses of preeclampsia.Serum levels of tumor necrosis factor alpha (TNFα ) and interleukin 10(IL-10 )were measured by enzyme-linked immunosorbent assay (ELISA) . C reactive protein (CRP) was evaluated as inflammatory marker in preeclampsia.Our findings demonstrated that pre eclamptic state is associated with high levels of pro inflammatory cytokine TNFα (p < 0.05) and C.R.P. By contrast, normotensive pregnancy evolved high levels of regulatory cytokine Il-10 .The present study supports the hypothesis of altered immune response in preeclampsia. | ||||
Keywords | ||||
C-reactive protein (CRP); pro inflammatory cytokine(TNFα ); regulatory cytokine (IL-10 ) | ||||
Statistics Article View: 119 PDF Download: 122 |
||||