NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE | ||||
Al-Azhar Bulletin of Science | ||||
Article 2, Volume 18, Issue 1-A, June 2007, Page 151-161 PDF (311.73 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/absb.2007.10871 | ||||
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Author | ||||
FATHI A. ABU-SHANAB* | ||||
Chemistry Department, Faculty of Science, Al-Azhar University, Assiut 71524, | ||||
Abstract | ||||
Treatment of N-aryl 2-chloroacetamides (2a-f) with sodium isopropoxide in isopropyl alcohol afforded 1,4-diarylppiperazine-2,5-dione (3a-f). Treatment of malononitrile dimer (9), ethyl cyanoacetate (11) and the arylidines of cyanothioacetamide (13) with DMFDMA afforded the corresponding enamines (10, 12 and 14) respectively. Reaction of 14 with either sodium ethoxide or sodium methoxide affords 5-cyano-4-ethoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (15) and 5-cyano-4-methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (16) respectively. | ||||
Keywords | ||||
1,4-DIARYLPIPERAZINE-2,5-DIONE; 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE | ||||
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