PHARMACOKINETICS AND BIOAVAILABILITY OF THIAMPHENICOL GLYCINATE HCL IN MALE GOATS | ||||
Kafrelsheikh Veterinary Medical Journal | ||||
Article 1, Volume 13, Issue 1, April 2015, Page 1-18 PDF (422.8 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/kvmj.2015.108730 | ||||
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Authors | ||||
A. H. Bogzil* 1; M. A. Tohamy2 | ||||
1Department of Pharmacology, toxicology and forensic medicine, Faculty of Veterinary Medicine, Omar Al Mukhtar University | ||||
2Pharmacology Department, Faculty of Veterinary Medicine, Beni-suef University, Egypt | ||||
Abstract | ||||
The Pharmacokinetic profile of thiamphenicol glycinate HCl was studied in male goats following single intravenous and intramuscular administration of 30 mg kg-1 b.wt. Thiamphenicol concentration in serum was determined by microbiological assay using Bacillus subtilis (ATCC 6633) as test organism. After intravenous injection the serum thiamphenicol concentration time course was found to obey two-compartment open model with distribution (t0.5(α)) and elimination (t0.5(β)) half lives of 0.0.06 ± 0.003 and 1.20 + 0.163 h., respectively. Total body clearance (ClB) and steady state volume of distribution (Vdss) were 1.025 ± 0.04 L kg-1 h-1 and 0.51± 0.010 L kg-1., respectively. After intramuscular administration the observed mean peak serum concentration (Cmax) was 6.89 ± 0.052 μg ml-1 achieved after maximum time (tmax) of 1.53 ± 0.08 hour post-injection.The systemic bioavailability after intramuscular was 87.61 % . The plasma protein binding percent was 13.3%. | ||||
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Keywords | ||||
PHARMACOKINETICS; BIOAVAILABILITY; THIAMPHENICOL GLYCINATE HCL; MALE GOATS | ||||
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