Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.
Nasr, M., Hassan, D., Dawah, A., Hemeida, A., Abd El-Azeem, R. (2016). Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.. EKB Journal Management System, 2(7), 452-457. doi: 10.21608/jbaar.2016.108733
Mahmoud Imam Nasr; Dalia Reda Mahmoud Hassan; Abd El-Moniem A. Younis Dawah; Alaa A. Hemeida; Reham M. Abd El-Azeem. "Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.". EKB Journal Management System, 2, 7, 2016, 452-457. doi: 10.21608/jbaar.2016.108733
Nasr, M., Hassan, D., Dawah, A., Hemeida, A., Abd El-Azeem, R. (2016). 'Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.', EKB Journal Management System, 2(7), pp. 452-457. doi: 10.21608/jbaar.2016.108733
Nasr, M., Hassan, D., Dawah, A., Hemeida, A., Abd El-Azeem, R. Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.. EKB Journal Management System, 2016; 2(7): 452-457. doi: 10.21608/jbaar.2016.108733

Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.

Journal of Bioscience and Applied Research
Article 2, Volume 2, Issue 7, July 2016, Page 452-457  XML PDF (440.48 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2016.108733
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Authors
Mahmoud Imam Nasr1; Dalia Reda Mahmoud Hassan1; Abd El-Moniem A. Younis Dawah2; Alaa A. Hemeida3; Reham M. Abd El-Azeem4
1Molecular biology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City
2Public health and community medicine Dept., Faculty of Medicine, Benha University
3Bioinformatics Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City.
4Environmental Biotechnology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City
Abstract
Viral hepatitis and infection with Schistosma mansoni are the main causes of chronic liver disease and liver cirrhosis. Infection with hepatitis C virus (HCV) is the most important public health problem in Egypt. This study was done to determine the association between Schistosma and hepatitis C, by testing liver function using the following biochemical tests: Total and direct bilirubin, TB-DB, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), serum albumin, and liver biopsy, and make comparison between them. The results indicated that 60 % of cases HCV and Bilharzias reveal abnormal results accompanied by chronic liver disease, when compared to the 40% of normal result. All cases were subjected to routine biochemical liver function tests and serum antibodies to bilharziasis. The results showed that, ALT and AST were highly significant difference in group hepatitis C only compared with control group which showed normal results. The other liver functions such as ALP, TB and DB were high in patients with hepatitis C and Biharziasis compared with control group with statically significant difference P<0.05 . Also, the results showed histopatholigical changes (fibrosis and cirrhosis) in patients with Hepatitis C and Hepatitis C and Biharziasis after taking liver biopsy from both patients.
Keywords
Hepatitis C; Schistosoma mansoni; Liver function tests; Histopathology; Co infection
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