TNF ‐ Α And Glycemic Control in T2D: A Single Center Study | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 20, Volume 80, Issue 3, July 2020, Page 1074-1078 PDF (453.48 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2020.108883 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Fatima Al Taher; Adel Abd El Mohsen Ghorab; Ali Mostafa Shendi; Asmaa Mohamed Hosny Esh; Ahmed Embaby | ||||
| Abstract | ||||
| Background: Type 2 diabetes mellitus (T2D) is a global heath burden that is recently viewed as a state of chronic low-grade inflammation involving activation of immunological and inflammatory responses. Tumor necrosis factor‐ alpha (TNF‐ α) is a well-known pro inflammatory cytokine produced mainly by adipose tissues that plays a predominant role in development of insulin resistance in obese population. Thus, several researchers have hypothesized that circulating TNF‐ α levels in diabetic patients can influence diabetic control Objectives: The aim of the study was to analyse the relationship between the proinflammatory cytokine TNFα, C-reactive protein (CRP), ESR and HbA1c in patients with type2 diabetes mellitus to evaluate the impact of these inflammatory markers on glycemic control. Subjects and methods: This study included eighty-four Type 2 DM patients from patients admitted to internal medicine department in Zagazig University Hospitals. Routine laboratory investigations, TNF -α, ESR, CRP and HbA1c were collected and analyzed in all studied population. Results: We found significant association between serum TNF-α and serum HbA1c. These results supports the impact of TNF-α on glycemic control in T2D patients. Conclusion: Serum TNF-α and CRP levels are elevated in type-2 diabetic patients and their levels correlate with level of HBA1c. This supports the impact of inflammation on glycemic control. | ||||
| Keywords | ||||
| HbA1c; C-reactive protein; Tumor necrosis factor-α; Type 2 diabetes mellitus | ||||
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