Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats
Embaby, E., Marghani, B., Elghareeb, M., Elmetwally, M., Abu-Heakal, N. (2020). Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats. EKB Journal Management System, 18(1), 1-5. doi: 10.21608/kvmj.2020.21123.1000
Eman Embaby; Basma H. Marghani; Mona M. Elghareeb; Mohamed A. Elmetwally; Nabil Abu-Heakal. "Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats". EKB Journal Management System, 18, 1, 2020, 1-5. doi: 10.21608/kvmj.2020.21123.1000
Embaby, E., Marghani, B., Elghareeb, M., Elmetwally, M., Abu-Heakal, N. (2020). 'Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats', EKB Journal Management System, 18(1), pp. 1-5. doi: 10.21608/kvmj.2020.21123.1000
Embaby, E., Marghani, B., Elghareeb, M., Elmetwally, M., Abu-Heakal, N. Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats. EKB Journal Management System, 2020; 18(1): 1-5. doi: 10.21608/kvmj.2020.21123.1000

Protective effect of L-arginine against renal damage induced by cadmium and lead intoxication in rats

Kafrelsheikh Veterinary Medical Journal
Article 1, Volume 18, Issue 1, August 2020, Page 1-5  XML PDF (848.17 K)
Document Type: Original Article
DOI: 10.21608/kvmj.2020.21123.1000
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Authors
Eman Embaby email 1; Basma H. Marghani1; Mona M. Elghareeb1; Mohamed A. Elmetwally2; Nabil Abu-Heakal1
1Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
2Department of Obstetrics, Reproduction and Artificial Insemination. Faculty of Veterinary Medicine, Mansoura University
Abstract
Objective: This study was conducted to investigate the protective effect of L-arginine (L-Arg) on renal damage induced by cadmium (Cd) and lead (Pb) toxicities in rats.
Methods: Thirty-six healthy mature male albino rats were allocated into six experimental groups (n=6/group): control group, L-arginine group (L-Arg) administered 200 mg/kg b.wt L-Arg, cadmium chloride group (Cd) received 5 mg/kg b.wt Cd chloride, lead acetate group (Pb) received 25 mg/kg b.wt Pb acetate, L-Arg + Cd chloride group (L-Arg + Cd) received L-Arg 30 minutes prior to Cd chloride, and L-Arg + Pb acetate group (L-Arg + Pb) received L-Arg 30 minutes prior to Pb acetate. All treatments were given orally once daily for 15 days.
Results: The results revealed that exposure of rats to Cd chloride and Pb acetate resulted in a significant (p < 0.05) increase in serum creatinine, urea, uric acid, and renal malondialdehyde (MDA) levels and a significant  (p < 0.05) decrease in superoxide dismutase (SOD), catalase (CAT),  reduced glutathione (GSH) activities in kidney and induced histopathological alterations in kidney tissue. However, pretreatment with L-Arg attenuated all deleterious effects induced by Pb and Cd.
Conclusion:  The present results support the hypothesis that the amino acid, L-arginine, is an efficient antioxidant capable of minimizing the hazard effects of cadmium chloride and lead acetate on the kidney.       
 
 

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Keywords
L-arginine; Cadmium; Lead; Kidney; Oxidative stress
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