Biological Mechanisms of Lithium separately and in combination with Caffeine in Palatogenesis in Albino Rat | ||||
| Al-Azhar Dental Journal for Girls | ||||
| Article 8, Volume 5, Supplement, October 2018, Page 471-476 PDF (1.24 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjg.2018.109378 | ||||
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| Authors | ||||
| Hagar Abdel Sabour Saad* 1; Mona H Farid2; Heba Ahmed Adawy3 | ||||
| 1Demonstrator of Oral and Dental Biology, Oral and Dental Biology Department, Faculty of Dental Medicine, Al-Azhar University for Girls. | ||||
| 2Professor and Head of Oral and Dental Biology Department, Faculty of Dental Medicine, Al- Azhar University for Girls. | ||||
| 3Assistant Professor of Oral and Dental Biology, Oral and Dental Biology Department, Faculty of Dental Medicine, Al-Azhar University for Girls. | ||||
| Abstract | ||||
| Purpose: The purpose of this study was to evaluate the Biological Mechanisms of Lithium separately and in combination with Caffeine in Palatogenesis in Albino Rat Materials and Methods: Thirty six adult rats were used in this study, twenty four female and twelve male rats, after mating procedures and confirmation of pregnancy the pregnant rats were divided into 3 groups :group1(control) , which consists of six pregnant rats and were not receive any medication during gestation, group2’ Which consists of nine pregnant rats and were received prianil (lithium carbonate) 200mg/kg intragasteric During the period of ( 6th to 15th ) day of gestation &group 3: Which consists of nine pregnant rats and were received prianil (lithium carbonate) 200mg/kg rat and caffeine 18mg/kg rat intragasteric durig the same period. The fetuses were obtained from mother were decapitated and the heads were fixed in buffered formaline for at least 3 hours. The specimens were collected, prepared and examined by routine haematoxylin &eosin and immunostained by (Ki-67) marker. Results: at 16, 18 and 21 days of gestation, the greatest mean value was recorded in group II, followed by group III, with the least value recorded in group I. Both group I and III revealed a decrease in area percent of (Ki-67) throughout the study, whereas in group II revealed an increase. Conclusions: The study offers a clear evidence that lithium during pregnancy causing cleft palate in fetus and caffeine could efficiently antagonize the teratogenicity of high doses of lithium on palate when both administrated. | ||||
| Keywords | ||||
| Lithium carbonate; Caffeine; cleft palate; Ki-67 | ||||
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