The utility of biomarkers in the discrimination of acute coronary syndrome patients | ||||
Journal of Bioscience and Applied Research | ||||
Article 7, Volume 5, Issue 1, March 2019, Page 60-74 PDF (537.96 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jbaar.2019.109399 | ||||
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Authors | ||||
Mohamed M. Omran* 1; Faten M. Zahran2; Mohamed Kadry3; Arafa A. M. Belal3; Hesham S. Abd Alsamie4 | ||||
1Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt | ||||
2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt | ||||
3Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt | ||||
4Clinical Pathology Department, Faculty of Medicine, New Damietta, Al-Azhar University, Egypt | ||||
Abstract | ||||
Background: The assessment of acute coronary syndrome (ACS) provides useful data not only for identification but also for therapeutic decisions. Objective: To develop a score based on cardiac biomarker for the early diagnosis of ACS patients. Methods: Serum concentrations of myeloperoxidase (MPO) and monocyte chemoattractant protein-1 (MCP-1) beside cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) were measured in a total 200 chest pain patients represented in two groups (estimation and validation). The diagnostics value of biomarkers for discriminating ACS patients was evaluated by area under the receiver-operating characteristic curve (AUC). Multivariate discriminant analysis (MDA) was used to create a predictive score. Results: A novel score depends on a combination of cTnI, CK-MB, MPO, and MCP-1 produces AUCs of 0.93 for discriminating ACS patients and 0.90 for acute myocardial infarction (AMI). This score correctly classified 95% of ACS patients and 93% of AMI patients with good efficiencies were 88.3% and 81%; respectively. This score had similar results in the validation study. Conclusion: Four biomarkers in combination yield a novel score to help in the early and safe prediction of ACS and AMI. | ||||
Keywords | ||||
Myeloperoxidase; Monocyte chemoattractant protein-1, Acute coronary syndrome | ||||
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