Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
Mayah, F., Mansour, H., Mohamed, R., Marey, N., Mohammed, K., Ibrahim, A., Osman, T. (2021). Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients. EKB Journal Management System, 3(1), 967-975. doi: 10.21608/ijma.2020.31335.1130
Fatma Ibrahim Mayah; Hayam Hamza Mansour; Ragaa Ramadan Mohamed; Nadia Kamal Marey; Khaled Younis younis Mohammed; Amr Mohamed Ibrahim; Tarek Fakhr eldeen Osman. "Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients". EKB Journal Management System, 3, 1, 2021, 967-975. doi: 10.21608/ijma.2020.31335.1130
Mayah, F., Mansour, H., Mohamed, R., Marey, N., Mohammed, K., Ibrahim, A., Osman, T. (2021). 'Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients', EKB Journal Management System, 3(1), pp. 967-975. doi: 10.21608/ijma.2020.31335.1130
Mayah, F., Mansour, H., Mohamed, R., Marey, N., Mohammed, K., Ibrahim, A., Osman, T. Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients. EKB Journal Management System, 2021; 3(1): 967-975. doi: 10.21608/ijma.2020.31335.1130

Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients

International Journal of Medical Arts
Article 10, Volume 3, Issue 1, January 2021, Page 967-975  XML PDF (1.1 MB)
Document Type: Original Article
DOI: 10.21608/ijma.2020.31335.1130
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Authors
Fatma Ibrahim Mayah email 1; Hayam Hamza Mansour1; Ragaa Ramadan Mohamed1; Nadia Kamal Marey1; Khaled Younis younis Mohammed2; Amr Mohamed Ibrahim3; Tarek Fakhr eldeen Osman4
1Department of Internal Medicine, Faculty of Medicine for Girls, Al Azhar University, Egypt
2Department of Internal Medicine National Research Center, Egypt
3Department of Clinical Pathology National Research Center, Egypt
4Department of Nephrology, National Institute of Urology and Nephrology, Egypt
Abstract
Background: Vascular calcification is a common complication in end-stage renal disease patients and the leading cause of morbidity and mortality.
Aim of the work: The current work aimed to evaluate the possible relationship between vitamin D receptor gene polymorphism FokI with fetuin-A and intact parathormone hormone in Egyptian hemodialysis patients.
Patient and Methods: This study is a cross-sectional study including 50 hemodialysis patients attending the hemodialysis unit in Al-Zahra University Hospital and 30 apparently healthy persons as a control group. For all studied subjects, a detailed history was taken, physical examination, carotid intima-media thickness by carotid duplex, echocardiography, Laboratory investigations included serum levels of calcium, phosphorus, iPTH, fetuin, and genotype frequency by PCR
Results: There was a highly significant increase in carotid intimal media thickness in the patient group Vs. control group & a highly significant decrease in serum Fetuin-A in the patient's group Vs. control group. There was a significant difference in the genotype distribution of FokI polymorphism among patients and control. There were significant negative relationships between FF genotype and iPTH and a highly significant negative correlation between serum fetuin-A and iPTH in the patient group.
Conclusion: Vitamin D receptor gene FokI polymorphism FF genotyping is more frequent in hemodialysis patients who have higher iPTH and lower fetuin-A levels, which could identify the high-risk group susceptible to vascular calcification in hemodialysis patients. Further studies are needed.
Keywords
Vascular Calcification; Vitamin D Receptor Polymorphism; FokI; Fetuin-A; Parathormone Hormone
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