Mitochondrial Translocase Expression Profile in Renal Cancer | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 16, Volume 70, Issue 6, January 2018, Pages 974-979 PDF (491.97 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0044346 | ||
| Authors | ||
| Belal Ahmed Soliman1; Mohamed Hassany Ali* 1; Eman Ali Toraih2; Mohamed Abdelhamid Hasan Ahmed3 | ||
| 1Department of Zoology, Faculty of Science, Suez Canal University | ||
| 22 Department of Histology and Genetics, Faculty of Medicine, Suez Canal University | ||
| 3Department of Pathology, Faculty of Medicine, Suez Canal University | ||
| Abstract | ||
| Background: mitochondrial appropriate function depends on ideal mitochondrial translocation machinery, of which translocase of outer mitochondrial membrane (TOMM) have a vital role in normal functioning cell. Any disturbance in the translocation machinery leads to either tumorigenesis or apoptosis. Aim of the work: This study aimed to investigate the expression of TOMM34 in renal cell carcinoma (RCC). TOMM34 expression was assessed in 42 samples of RCC patients using immunohistochemistry technique. Results: immunohistochemical staining revealed significant accumulation of TOMM34 protein in RCC cases compared to their corresponding non-cancerous renal tissues. TOMM34 protein expression was significantly associated with age and gender categories in contrast to the other clinicopathological features. Conclusion: according to protein expression level this study demonstrated that TOMM34 is a marker of poor outcome in RCC. | ||
| Keywords | ||
| RCC; TOMM34; IHC | ||
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