Diagnostic utility of aquaporin-4 blood level in neonatal hypoxic ischemic encephalopathy | ||||
| Zagazig University Medical Journal | ||||
| Article 25, Volume 29, Issue 1.1, January 2023, Page 173-181 PDF (378.05 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2020.25067.1757 | ||||
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| Authors | ||||
Ehab Elbanna1; Noha Rezk2; Ahmed Abdel Moniem1; Sabah Abdel Rahman  1
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| 1Pediatrics Department, Faculty of Medicine, Zagazig University | ||||
| 2Medical Biochemistry Department, Faculty of Medicine, Zagazig University | ||||
| Abstract | ||||
| Background: In neonates, cerebral hypoxic-ischemia is the main cause of brain oedema which results in neurodevelopmental disfunction. After cerebral injury, Aquaporin-4 (AQP4) is reported to be overexpressed in the astrocytes. This study was conducted to evaluate using of the blood level of aquaporin-4 in diagnosis of hypoxic ischemic encephalopathy in neonates. Methods: Blood samples were collected from 30 neonates with hypoxic ischemic encephalopathy (HIE), sample (1) at age of 2 days while sample (2) at age of 7 days, and from 30 neonates control groups. The collected blood samples were used to measure aquaporin-4 level and creatine phosphokinase (CPK). Results: Aquaporin-4 at age of 2 days was found to be significantly higher in hypoxic patients than the control (220.83±98.85 vs. 135.51± 28.32 pg/ml). Moreover, the level of AQP4 at age of 7 day was 349.72±110.25 pg/ml. There was no significant difference in AQP4 level between preterm and full term hypoxic patients at age of 2 days, as the values were 275.33±69.72 pg/ml for preterm and 214.55±97.06 for full term. However, there was a significant difference in AQP4 level between preterm and full term hypoxic patients at age of 7 days, as the values were 453.93±66.19 pg/ml for preterm and 339.93± 108.22 pg/ml for full term. At age of 2 and 7 days, the severe hypoxic patients had significantly higher AQP4 levels than moderate or mild hypoxic patients. Conclusions: The obtained results indicate that serum Aquaporin-4 level and CPK enzyme activity could be used as early predictors in diagnosis of HIE. | ||||
| Keywords | ||||
| aquaporin-4; creatine phosphokinase; ischemic encephalopathy; neonates | ||||
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