Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.
El-Ghareeb, A., Abd el-Kadr, I., Al Ahwany, A., Ali, A., Hassan, O. (2016). Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.. EKB Journal Management System, 2(10), 661-669. doi: 10.21608/jbaar.2016.109492
Abd El-Wahab El-Ghareeb; Ibrahim Yahia Abd el-Kadr; Amr Tharwat Al Ahwany; Aziza Mansour Ali; Ola Ismail Hassan. "Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.". EKB Journal Management System, 2, 10, 2016, 661-669. doi: 10.21608/jbaar.2016.109492
El-Ghareeb, A., Abd el-Kadr, I., Al Ahwany, A., Ali, A., Hassan, O. (2016). 'Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.', EKB Journal Management System, 2(10), pp. 661-669. doi: 10.21608/jbaar.2016.109492
El-Ghareeb, A., Abd el-Kadr, I., Al Ahwany, A., Ali, A., Hassan, O. Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.. EKB Journal Management System, 2016; 2(10): 661-669. doi: 10.21608/jbaar.2016.109492

Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.

Journal of Bioscience and Applied Research
Article 3, Volume 2, Issue 10, October 2016, Page 661-669  XML PDF (575.5 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2016.109492
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Authors
Abd El-Wahab El-Ghareeb1; Ibrahim Yahia Abd el-Kadr1; Amr Tharwat Al Ahwany2; Aziza Mansour Ali3; Ola Ismail Hassan3
1Zoology Department, Faculty of Science, Cairo University, Egypt.
2Andrology Department, Faculty of Medicine, Cairo University, Egypt
3Obstetrics & gynecology department, International Islamic center for population studies and research, Al-Azhar University
Abstract
The present study evaluated the effect of calcium ionophore A23187 on sperm in intracytoplasmic sperm injection (ICSI) cycles using sperm from different sources. The 80 cycles evaluated were divided into four subgroups according to sperm quality and origin (normospermia- oligoathenoteratospermia–epidermal–testicular), subgroups were further split into experimental groups, depending on whether the spem treated or not treated with calcium ionophore. For each experimental subgroup, ICSI outcomes were compared between groups. In conclusion we found that using calcium ionophore increase the fertilization rate in case of sperm treatment with calcium ionophore before ICSI for oligoathenoteratospermia (OAT) & testicular subgroups, with enhancing embryos quality in testicular subgroup only
Keywords
Calcium ionophore A23187; fertilization rate; embryos quality; ICSI
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