A Potential Invasion-Promoting Role for Ezrin in Endometrial Carcinoma | ||||
| Research in Oncology | ||||
| Article 4, Volume 16, Issue 2, December 2020, Page 48-55 PDF (862.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/resoncol.2020.33873.1101 | ||||
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| Authors | ||||
Ahmed R. H. Ahmed   1; Ghada M. Yousef2; Mohamed S. E. Abdel-Raheem3; Eman M. S. Muhammad1
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| 1Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||||
| 2Department of Pathology, Sohag Cancer Center, Sohag, Egypt | ||||
| 3Department of Gynecology and Obstetrics, Faculty of Medicine, Sohag University, Sohag, Egypt | ||||
| Abstract | ||||
| Background:Ezrin is a cell membrane-cytoskeleton linker that is essential to maintain the normal cell shape and the integrity of cell-cell adhesion. Overexpression of ezrin is correlated with poor prognosis in several malignancies. Aim: To evaluate the expression of ezrin in hyperplastic and neoplastic endometrial tissues and to correlate its expression with the clinical and pathological parameters of endometrial carcinoma. Methods: Tissue sections of 66 specimens including 37 endometrial carcinoma, 16 atypical endometrial hyperplasia and 13 benign endometrial hyperplasia were evaluated for ezrin expression by immunohistochemistry. Results: Ezrin expression was detected in all endometrial carcinoma specimens and in 90% of hyperplasia. There was redistribution of ezrin from membranous expression in endometrial hyperplasia to diffuse cytoplasmic expression in endometrial carcinoma (p < 0.0001). Expression of ezrin was significantly higher in atypical compared to benign hyperplasia (p < 0.001) and it was relatively higher in endometrial carcinoma compared to atypical endometrial hyperplasia (p=0.086). Among the carcinoma specimens, expression of ezrin was significantly associated with invasion of myometrium (p=0.001), higher FIGO stage (p=0.008) and the presence of vascular tumor emboli (p=0.001). Muscle-invasive tumor cells expressed significantly higher levels of ezrin compared to non-invasive cells of the same tumor tissue (p < 0.0001). Tumor size, tumor grade and villoglandular morphology did not correlate significantly with ezrin expression. Conclusion: Ezrin was overexpressed in endometrial carcinoma and its expression was associated with the invasive potential of tumor cells. | ||||
| Keywords | ||||
| Carcinoma; Cytoplasmic Expression; Endometrium; Ezrin; Hyperplasia; Invasion | ||||
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