Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers
M. EL-Deen, I., Seleem, A., Alrefaey, A., Elsayed, E., Amin, A. (2021). Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers. EKB Journal Management System, 2(1), 1-7. doi: 10.21608/ajbas.2020.37514.1027
Ibrahim M. EL-Deen; Amal K. Seleem; Abdel Aziz A. Alrefaey; Elsherbiny Elsayed; Ateya Gomaa Amin. "Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers". EKB Journal Management System, 2, 1, 2021, 1-7. doi: 10.21608/ajbas.2020.37514.1027
M. EL-Deen, I., Seleem, A., Alrefaey, A., Elsayed, E., Amin, A. (2021). 'Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers', EKB Journal Management System, 2(1), pp. 1-7. doi: 10.21608/ajbas.2020.37514.1027
M. EL-Deen, I., Seleem, A., Alrefaey, A., Elsayed, E., Amin, A. Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers. EKB Journal Management System, 2021; 2(1): 1-7. doi: 10.21608/ajbas.2020.37514.1027

Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers

Alfarama Journal of Basic & Applied Sciences
Article 1, Volume 2, Issue 1, January 2021, Page 1-7  XML PDF (314.33 K)
Document Type: Original Article
DOI: 10.21608/ajbas.2020.37514.1027
View on SCiNiTO View on SCiNiTO
Authors
Ibrahim M. EL-Deen1; Amal K. Seleem2; Abdel Aziz A. Alrefaey3; Elsherbiny Elsayed4; Ateya Gomaa Amin email 5
1Department of Chemistry, Faculty of Science, Port Said University
2Department of Clinical Biochemistry, Faculty of Medicine
3Department of Gynocology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. .
4Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.
5Insurance of health
Abstract
Preeclampsia (PE) is the complexity the case of pregnancy with an indication of the presence of defective placentas, and inadequate blood supply to the placenta defect and endothelial dysfunction .the aim of study. The variation between endothelial growth factor angiogenesis (VEGF), placental growth factor (PlGF) and their receptors kinase domain that contains the receptor (KDR) and tyrosine kinase 1 (Flt-1) plays a valuable role in the pathophysiology of PE .We conducted a cross-sectional study of 50 women with Preeclampsia: 25 women with mild PE, and 25 patients with severe PE. While 24 pregnant women work normally with age as a control group. placental mRNA gene expression of KDR was measured using real time PCR ( RT/PCR),The mean of KDR expression was statistically significantly higher in the control group compared to any of the PE groups (p < /p>
Keywords
Preeclampsia; KDR; endothelial dysfunction; placental ischemia
Statistics
Article View: 221
PDF Download: 284